ArticleJournal of affective disorders2024
Plasma homocysteine and longitudinal change in cognitive function among urban adults.
Article in Journal of affective disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Development of a clinical nomogram to assess the risk of cognitive impairment in community-dwelling middle-aged and older adults.BMC neurology · 2026Article
- Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study.Frontiers in aging neuroscience · 2026Article
- Socio-environmental and health-related factors and their association with longitudinal change in brain neuroimaging markers through the plasma metabolome among UK adults: An additive Bayesian network analysis.Brain, behavior, & immunity - health · 2025Article
- The Interplay of Food Insecurity, Diet Quality, and Dementia Status in their Association with All-Cause Mortality Among Older US Adults in the Health and Retirement Study 2012-2020.Journal of the Academy of Nutrition and Dietetics · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundCross-sectional and longitudinal studies have inconsistently linked cognitive performance and change over time to an elevated level of homocysteine (Hcy), with few conducted among urban adults.
methodsLongitudinal data [Visit 1 (2004-2009) and Visit 2 (2009-2013)] were analyzed from up to 1430 selected Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) participants. Baseline and follow-up blood Hcy was measured, while 11 cognitive function test scores were assessed at either of these two visits. Overall, sex- and race-stratified associations were evaluated using mixed-effects linear regression models, adjusting for key potential confounders. Interaction effects between Hcy and serum levels of folate and vitamin B-12 were also tested.
resultsWe found that greater LnHcy
conclusionsIn summary, sex- and race-specific adverse association between elevated Hcy and cognitive performance over time were detected among middle-aged urban adults, in domains of attention, visuo-spatial memory and executive functioning.
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Registered trials
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