Evidence map›Paper›PMID 39134057›Full record

ArticleACS synthetic biology2024

Characterizing and Tailoring the Substrate Profile of a γ-Glutamyltransferase Variant.

David Mueller, Remo Baettig, Tilmann Kuenzl, Emilio Rodríguez-Robles, Tania Michelle Roberts, Philippe Marlière, Sven Panke

Abstract read
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David MuellerDepartment of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland.
Remo BaettigDepartment of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland.ORCID 0009-0002-2589-2618
Tilmann KuenzlDepartment of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland.
Emilio Rodríguez-RoblesDepartment of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland.ORCID 0000-0002-9404-5300
Tania Michelle RobertsDepartment of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland.ORCID 0000-0001-9518-3011
Philippe MarlièreTESSSI, The European Syndicate of Synthetic Scientists and Industrialists, 75002 Paris, France.
Sven PankeDepartment of Biosystems Science and Engineering, ETH Zürich, 4056 Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xenobiology is an emerging field that focuses on the extension and redesign of biological systems through the use of laboratory-derived xenomolecules, which are molecules that are new to the metabolism of the cell. Despite the enormous potential of using xenomolecules in living organisms, most noncanonical building blocks still need to be supplied externally, and often poor uptake into cells limits wider applicability. To improve the cytosolic availability of noncanonical molecules, a synthetic transport system based on portage transport was developed, in which molecules of interest "cargo" are linked to a synthetic transport vector that enables piggyback transport through the alkylsulfonate transporter (SsuABC) of

Indexed as

Escherichia coligamma-GlutamyltransferaseEscherichia coli ProteinsKineticsSubstrate SpecificityTandem Mass SpectrometryEscherichia coli Proteinsgamma-Glutamyltransferasedirected evolutionenzymatic releasesynthetic biologysynthetic transport systemxenobiologyxenomolecules

Identifiers

PMID39134057
PMCPMC11421214

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.