Evidence map›Paper›PMID 39134005›Full record

ArticleCardiorenal medicine2024

Galectin-3 and Soluble CD146 Identify Cardiorenal Injuries in Severe Burn Patients: A Biomarker-Based Approach.

Louis Boutin, Sabri Soussi, Angèle Garcia Lavello, Elisabeth Masson Fron, Banjamin Deniau, Matthieu Legrand, Marcel Blot-Chabaud, Stefanny Muriel Figueroa, Christos Envangelos Chadjichristos, Feriel Azibani and 1 more

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Article in Cardiorenal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Louis BoutinDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, AP-HP, Saint-Louis Hospital, DMU Parabol, FHU PROMICE, Université de Paris, Paris, France.
Sabri SoussiDepartment of Anesthesia and Pain Management, University Health Network (UHN), Women's College Hospital, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
Angèle Garcia LavelloDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, AP-HP, Saint-Louis Hospital, DMU Parabol, FHU PROMICE, Université de Paris, Paris, France.
Elisabeth Masson FronDépartement de Biochimie et Biologie Moléculaire, Hôpitaux Lariboisière-Fernand Widal, Paris, France.
Banjamin DeniauDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, AP-HP, Saint-Louis Hospital, DMU Parabol, FHU PROMICE, Université de Paris, Paris, France.
Matthieu LegrandDivision of Critical Care Medicine, Department of Anesthesiology and Peri-Operative Medicine, University of California - UCSF Medical Center, San Francisco, California, USA.
Marcel Blot-ChabaudAix-Marseille Univ, INSERM INRA, C2VN Marseille, Marseille, France.
Stefanny Muriel FigueroaINSERM, UMR 1155, CORAKID, Tenon Hospital, Sorbonne Université, Paris, France.
Christos Envangelos ChadjichristosINSERM, UMR 1155, CORAKID, Tenon Hospital, Sorbonne Université, Paris, France.
Feriel AzibaniINSERM, UMR 942, MASCOT: Cardiovascular Marker in Stress Condition, Lariboisière Hospital, Université de Paris, Paris, France.
Fançois DépretDepartment of Anaesthesiology, Critical Care Medicine and Burn Unit, AP-HP, Saint-Louis Hospital, DMU Parabol, FHU PROMICE, Université de Paris, Paris, France.

Funding

Identification of sub-phenotypes of severely ill burn patients and risk for secondary sepsis: SEPSISBURNR01GM151494 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Matthieu Legrand · 2023 to 2026
$1.5M
NIGMS NIH HHS R01 GM151494
6 · The paper itself

Abstract

introductionAcute kidney injury (AKI) and myocardial injury (MI) are severe conditions in patients with severe burn injury, and combination of both is even worst and is called the cardiorenal syndrome (CRS). Identifying a distinct cardiorenal phenotype could significantly enhance the management of these patients. Galectin-3 (Gal3) and soluble CD146 (sCD146) are biomarkers for renal and cardiac injuries. This study aims to assess the occurrence and reliability of these biomarkers in recognizing CRS in individuals who have been severely burn.

methodsThis study is a single-center prospective proof-of-concept study involving patients with severe burn injuries. Plasma samples for Gal3 and sCD146 measurements were collected daily during the initial 7 days following admission. CRS was defined after 24 h of admission by the association of AKI stage 1 or more (KDIGO definition) and MI defined on high sensitive troponin (hsTnT) (variation >20% baseline value or absolute value >40 ng/mL).

resultsForty patients met the inclusion criteria and were included in this study. Thirty-eight patients had CRS. The pooled values of Gal3 or combination of Gal3 and sCD146 values following 7 days after admission were associated with CRS with an odds ratio (OR) of 1.145 (95% CI: 1.081-1.211), p < 0.001, and 1.147 (95% CI: 1.085-1.212), p < 0.001, respectively. Gal3 values at admission (D0) had a predictive performance for CRS with an AUC of 0.78 (95% CI: 0.63-0.93), and this performance improved when using the combination of Gal3 and sCD146 values at admission (D0), with an AUC of 0.81 (95% CI: 0.66-0.96). Gal3 levels during the first 7 days were associated with patients experiencing AKI and no MI, with an OR of 1.129 (95% CI: 1.065-1.195), p < 0.001, and MI without AKI with an OR of 1.095 (95% CI: 1.037-1.167), p < 0.001. sCD146 alone was not associated with AKI without MI or MI without AKI and was poorly associated with CRS.

conclusionIn severely burned patients, CRS is a frequent and severe condition. Gal3 values during the first 7 days following admission were associated with CRS. The use of sCD146 with Gal3 improved prediction performance for CRS identification. The use of such biomarkers to identify CRS is important and needs to be confirmed in other studies.

Indexed as

Acute Kidney InjuryBiomarkersBurnsCD146 AntigenGalectin 3AdultAgedBlood ProteinsFemaleGalectinsHumansMaleMiddle AgedMyocardial InfarctionProspective StudiesBiomarkersBlood ProteinsCD146 AntigenGalectin 3GalectinsLGALS3 protein, humanMCAM protein, humanAcute kidney injuryBiomarkerCardiorenal syndromeIntensive care unitSevere burn

Identifiers

PMID39134005
PMCPMC13446008

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