Evidence map›Paper›PMID 39133871›Full record

ArticleGut microbes

Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa.

Amanda Mandarino Alves, Chiara Lecchi, Sharon Lopez, Alessia Stornetta, Prince P Mathai, Peter W Villalta, Satoshi Ishii, Emily P Balskus, Silvia Balbo, Alexander Khoruts

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Intestinal dysbiosis and colorectal cancer.Chinese medical journal · 2025
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amanda Mandarino AlvesDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN, USA.
Chiara LecchiDepartment of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Sharon LopezDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN, USA.
Alessia StornettaDepartment of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Prince P MathaiDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN, USA.
Peter W VillaltaMasonic Cancer Center, University of Minnesota, Minneapolis, MN, USA.
Satoshi IshiiDepartment of Soil, Water, and Climate, University of Minnesota, Minneapolis, MN, USA.
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Silvia BalboDepartment of Environmental Health Sciences, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Alexander KhorutsDepartment of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-3205-3188

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Mass Spectrometric Analytical Collaborations with Members of the Masonic Cancer Center of the University of MinnesotaR50CA211256 · NCI · UNIVERSITY OF MINNESOTA · PI Peter William Villalta · 2016 to 2026
$2.1M
NCI NIH HHS P30 CA077598NCI NIH HHS R50 CA211256
6 · The paper itself

Abstract

Colibactin is a recently characterized pro-carcinogenic genotoxin produced by

Indexed as

Cystic FibrosisDNA AdductsIntestinal MucosaMucusMutagensAdultBiopsyColonic PolypsColonoscopyEscherichia coliFemaleHumansMaleMiddle AgedPeptidesPolyketidescolibactinDNA AdductsMutagensPeptidesPolyketidescolibactincolon cancercystic fibrosismicrobiotapks+ E. coli

Identifiers

PMID39133871
PMCPMC11321416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.