ArticlePLoS pathogens2024
High sugar diets can increase susceptibility to bacterial infection in Drosophila melanogaster.
Article in PLoS pathogens, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Beyond the germ: Rethinking implant-related infections as a host-microbiota-biomaterial ecosystem.Biofilm · 2026Review
- Atg8 orchestrates stress-responsive chromatin programs across immunity and metabolism.bioRxiv : the preprint server for biology · 2026Article
- Effects of a High-Glucose Diet onACS omega · 2026Article
- Diet impacts the effects of thermal stress on infection outcomes.BMC ecology and evolution · 2026Article
- Sex-specific effects of cereal-based diets on longevity and healthspan in Drosophila melanogaster.Biogerontology · 2026Article
- Impact of allyl-isothiocyanate and high sucrose diet on antimicrobial peptide expression and survival inFrontiers in immunology · 2026Article
- Host plant nutrition drives fitness outcomes in the cactus specialist Drosophila mettleri.PloS one · 2026Article
- The Gut Microbiota ofMicroorganisms · 2025Review
- Commensal acidification of specific gut regions produces a protective priority effect against enteropathogenic bacterial infection.Applied and environmental microbiology · 2025Article
- Review
- Chronic bacterial infections exert metabolic costs in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- Ketogenic diet in treating sepsis-related acquired weakness: is it friend or foe?Frontiers in nutrition · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Overnutrition with dietary sugar can worsen infection outcomes in diverse organisms including insects and humans, through generally unknown mechanisms. In the present study, we show that adult Drosophila melanogaster fed high-sugar diets became more susceptible to infection by the Gram-negative bacteria Providencia rettgeri and Serratia marcescens. We found that P. rettgeri and S. marcescens proliferate more rapidly in D. melanogaster fed a high-sugar diet, resulting in increased probability of host death. D. melanogaster become hyperglycemic on the high-sugar diet, and we find evidence that the extra carbon availability may promote S. marcescens growth within the host. However, we found no evidence that increased carbon availability directly supports greater P. rettgeri growth. D. melanogaster on both diets fully induce transcription of antimicrobial peptide (AMP) genes in response to infection, but D. melanogaster provided with high-sugar diets show reduced production of AMP protein. Thus, overnutrition with dietary sugar may impair host immunity at the level of AMP translation. Our results demonstrate that dietary sugar can shape infection dynamics by impacting both host and pathogen, depending on the nutritional requirements of the pathogen and by altering the physiological capacity of the host to sustain an immune response.
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