Evidence map›Paper›PMID 39133695›Full record

ArticleGenetics and molecular biology2024

Investigation of genetic markers associated to type 2 diabetes mellitus in Santarém-Pará.

Adjanny Estela Santos de Souza, Caio Henrique Silva da Silva, Rita de Cássia Silva de Oliveira, Ana Paula Araújo Guimarães, Aylla Núbia Lima Martins da Silva, Isabela Guerreiro Diniz, Haiala Soter Silva de Oliveira, Diego Sarmento de Sousa, Fernanda Andreza de Pinho Lott Figueiredo, Greice de Lemos Cardoso Costa and 1 more

Abstract read
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In one paragraph

Article in Genetics and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Association of Genetic Variants ofInternational journal of endocrinology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adjanny Estela Santos de SouzaUniversidade do Estado do Pará, Faculdade de Medicina, Departamento de Morfologia e Ciências Fisiológicas, Belém, PA, Brazil.ORCID http://orcid.org/0000-0001-9054-4535
Caio Henrique Silva da SilvaUniversidade do Estado do Pará, Faculdade de Medicina, Departamento de Morfologia e Ciências Fisiológicas, Belém, PA, Brazil.ORCID http://orcid.org/0000-0003-4917-1540
Rita de Cássia Silva de OliveiraUniversidade do Estado do Pará, Faculdade de Medicina, Departamento de Morfologia e Ciências Fisiológicas, Belém, PA, Brazil.ORCID http://orcid.org/0000-0001-9382-7573
Ana Paula Araújo GuimarãesUniversidade do Estado do Pará, Faculdade de Medicina, Departamento de Morfologia e Ciências Fisiológicas, Belém, PA, Brazil.
Aylla Núbia Lima Martins da SilvaUniversidade do Estado do Pará, Faculdade de Medicina, Departamento de Morfologia e Ciências Fisiológicas, Belém, PA, Brazil.ORCID http://orcid.org/0000-0002-2299-3301
Isabela Guerreiro DinizUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.ORCID http://orcid.org/0000-0002-7827-6328
Haiala Soter Silva de OliveiraUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.ORCID http://orcid.org/0009-0003-3700-5585
Diego Sarmento de SousaUniversidade Federal do Oeste do Pará (UFOPA), Santarém, PA, Brazil.ORCID http://orcid.org/0000-0001-5637-5985
Fernanda Andreza de Pinho Lott FigueiredoUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.
Greice de Lemos Cardoso CostaUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.ORCID http://orcid.org/0000-0002-8916-0283
João Farias GuerreiroUniversidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Genética Humana e Médica, Belém, PA, Brazil.ORCID http://orcid.org/0000-0003-1979-3656

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic, epigenetic and environmental factors play an important role in the genesis of Type 2 Diabetes Mellitus (T2D). In the genetic context, one of the strategies used to investigate possible associations with diabetes is the search for Single Nucleotide Polymorphisms (SNPs), involving the comparison of alelle frequencies, the phenotypic variations and other relevant factors, such as environmental influences and lifestyle choices, Thus, the aim of this study was to find the relationship of risk variants for T2D in SNPs (rs4994) in the ADRB3 gene; (rs1799854) in the ABCC8 gene; (rs7901695 and rs12255372) in the TCF7L2 gene; and (rs8050136) in the FTO gene in a sample of the population of the municipality of Santarém (PA), Brazilian Amazon, in the northern region of Brazil. ABCC8 (rs1799854 C>T) showed a statistically significant association with T2D. Each chosen gene and SNP has been previously implicated in T2D risk according to existing scientific literature, owing to their roles in glucose regulation and body fat.

Identifiers

PMID39133695
PMCPMC11308377

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.