ArticleCell reports2024
Adaptive robustness through incoherent signaling mechanisms in a regenerative brain.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- A single brief cue leaves a day-long internal state imprint in planarians.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense.bioRxiv : the preprint server for biology · 2025Article
- Neuropeptide-mediated temporal sensory filtering in a primordial nervous system.bioRxiv : the preprint server for biology · 2024Article
- A genetic and microscopy toolkit for manipulating and monitoring regeneration in Macrostomum lignano.Cell reports · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
Animal behavior emerges from collective dynamics of neurons, making it vulnerable to damage. Paradoxically, many organisms exhibit a remarkable ability to maintain significant behavior even after large-scale neural injury. Molecular underpinnings of this extreme robustness remain largely unknown. Here, we develop a quantitative pipeline to measure long-lasting latent states in planarian flatworm behaviors during whole-brain regeneration. By combining >20,000 animal trials with neural network modeling, we show that long-range volumetric peptidergic signals allow the planarian to rapidly restore coarse behavior output after large perturbations to the nervous system, while slow restoration of small-molecule neuromodulator functions refines precision. This relies on the different time and length scales of neuropeptide and small-molecule transmission to generate incoherent patterns of neural activity that competitively regulate behavior. Controlling behavior through opposing communication mechanisms creates a more robust system than either alone and may serve as a generalizable approach for constructing robust neural networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.