Evidence map›Paper›PMID 39133536›Full record

SynthesisJournal of medical microbiology2024

Mapping the oral resistome: a systematic review.

Smitha Sukumar, Zalmay Rahmanyar, Hagaar Q El Jurf, William S Akil, Jafar Hussain, F Elizabeth Martin, Kanchana Ekanayake, Elena Martinez

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Smitha SukumarFaculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2000, Australia.
Zalmay RahmanyarFaculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2000, Australia.
Hagaar Q El JurfFaculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2000, Australia.
William S AkilFaculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2000, Australia.
Jafar HussainFaculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2000, Australia.
F Elizabeth MartinFaculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2000, Australia.
Kanchana EkanayakeFaculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2000, Australia.
Elena MartinezFaculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, 2000, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studying individual ecological niches within the oral cavity is a logical first step to understanding the distribution of antimicrobial resistance genes (ARGs); however, it is not representative of the whole oral resistome. The aim of our systematic review was to provide a map of the oral resistome by reviewing the composition of individual niches. A total of 580 papers were retrieved from a search of all English language publications investigating the presence of oral ARGs in five electronic databases between January 2015 and August 2023. Fifteen studies [10 PCR and 5 next-generation sequencing (NGS)] were included in this review. The heterogeneity of methods precluded meta-analysis. ARGs are present throughout the oral cavity with 158 unique ARGs identified across 6 locations - supra and sub-gingival biofilm, mucosa, oropharynx, root canal system (RCS) and saliva. The supragingival biofilm had the highest resistome richness, while the RCS had the least. Tetracycline was the dominant antimicrobial resistance (AMR) class found. Three core genes were identified -

Indexed as

BiofilmsDrug Resistance, BacterialMouthAnti-Bacterial AgentsBacteriaGenes, BacterialHigh-Throughput Nucleotide SequencingHumansSalivaAnti-Bacterial Agentsantimicrobial resistanceantimicrobial resistance genesoral cavityresistomesystematic review

Identifiers

PMID39133536
PMCPMC11318793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.