Evidence map›Paper›PMID 39133525›Full record

ArticleJournal of the American Chemical Society2024

In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe.

Amber M Scharnow, Amy E Solinski, Sebastian Rowe, Ines Drechsel, Hua Zhang, Elana Shaw, Julia E Page, Hui Wu, Stephan A Sieber, William M Wuest

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Repurposing a drug to punish carbapenem-resistantProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amber M ScharnowDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Amy E SolinskiDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0003-2124-4613
Sebastian RoweDepartment of Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.
Ines DrechselDepartment of Chemistry, Center for Functional Protein Assemblies, Technical University of Munich, Garching D-85747, Germany.ORCID 0000-0002-3002-2978
Hua ZhangDepartments of Pediatric Dentistry, Microbiology, Schools of Dentistry and Medicine, University of Alabama at Birmingham, Birmingham 35294, Alabama, United States.
Elana ShawDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.
Julia E PageDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts 02115, United States.ORCID 0000-0002-9884-2382
Hui WuDepartments of Pediatric Dentistry, Microbiology, Schools of Dentistry and Medicine, University of Alabama at Birmingham, Birmingham 35294, Alabama, United States.ORCID 0000-0003-1694-3954
Stephan A SieberDepartment of Chemistry, Center for Functional Protein Assemblies, Technical University of Munich, Garching D-85747, Germany.ORCID 0000-0002-9400-906X
William M WuestDepartment of Chemistry, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0002-5198-7744

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infectionsR01AI148752 · NIAID · HARVARD MEDICAL SCHOOL · PI Daniel Kahne, Suzanne Walker · 2020 to 2026
$5.5M
Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026
$4.8M
Studies on the Biological Mechanisms of AntibioticsR01AI149778 · NIAID · HARVARD UNIVERSITY · PI Daniel Kahne · 2020 to 2026
$4.7M
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3M
PORT (Portland Oral health Research Training)T90DE030859 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI WU, HUI · 2021 to 2025
$2.1M
Tool Compounds to Probe Multispecies Biofilms in the Human Oral MicrobiomeR01DE025837 · NIDCR · TEMPLE UNIV OF THE COMMONWEALTH · PI WUEST, WILLIAM M · 2016 to 2020
$1.8M
NIAID NIH HHS R01 AI148752NIAID NIH HHS R01 AI149778NIDCR NIH HHS R01 DE022350NIDCR NIH HHS R01 DE025837NIDCR NIH HHS T90 DE030859NIGMS NIH HHS R35 GM119426NIGMS NIH HHS T32 GM007753
6 · The paper itself

Abstract

Natural products are important precursors for antibiotic drug design. These chemical scaffolds serve as synthetic inspiration for chemists who leverage their structures to develop novel antibacterials and chemical probes. We have previously studied carolacton, a natural product macrolactone from

Indexed as

BiofilmsAnti-Bacterial AgentsBacterial ProteinsHydrolasesLactonesMolecular ProbesN-Acetylmuramoyl-L-alanine AmidaseAnti-Bacterial AgentsBacterial ProteinsHydrolasesLactonesMolecular ProbesN-Acetylmuramoyl-L-alanine Amidase

Identifiers

PMID39133525
PMCPMC11345752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.