Evidence map›Paper›PMID 39133449›Full record

ArticleAnnals of surgical oncology2024

Survival Outcome Superiority of Total Pharyngolaryngectomy Compared with Chemoradiotherapy for T4aM0 Hypopharyngeal Squamous Cell Carcinoma: A Nationwide Database Study of Japan.

Go Omura, Kohtaro Eguchi, Seiichi Yoshimoto, Yoshitaka Honma, Chihiro Fushimi, Toshihiko Sakai, Yoshifumi Matsumoto, Azusa Sakai, Megumi Kitayama, Daisuke Kawakita and 4 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Go OmuraDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan. goomura@msn.com.ORCID http://orcid.org/0000-0003-1042-3667
Kohtaro EguchiDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Seiichi YoshimotoDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Yoshitaka HonmaDepartment of Head and Neck and Esophageal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
Chihiro FushimiDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Toshihiko SakaiDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Yoshifumi MatsumotoDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Azusa SakaiDepartment of Head and Neck Surgery, National Cancer Center Hospital, Tokyo, Japan.
Megumi KitayamaThe Japan Society for Head and Neck Cancer, Tokyo, Japan.
Daisuke KawakitaThe Japan Society for Head and Neck Cancer, Tokyo, Japan.
Tadaaki KiritaThe Japan Society for Head and Neck Cancer, Tokyo, Japan.
Takeshi KodairaThe Japan Society for Head and Neck Cancer, Tokyo, Japan.
Munenaga NakamizoThe Japan Society for Head and Neck Cancer, Tokyo, Japan.
Ken-Ichi NibuThe Japan Society for Head and Neck Cancer, Tokyo, Japan.

Funding

the Japan Society for the Promotion of Science (JSPS) KAKENHI 21K16849the Japan Society for the Promotion of Science (JSPS) KAKENHI 24K12662
6 · The paper itself

Abstract

backgroundThe purpose of this study is to elucidate whether total pharyngolaryngectomy (TPL) or chemoradiotherapy (CRT) provides a better prognostic outcome in patients with T4aM0 hypopharyngeal carcinoma (HPSCC) using a nationwide database.

methodsAll data were obtained from the Head and Neck Cancer Registry of Japan, and information from patients who were newly diagnosed with T4aM0 HPSCC between 2011 and 2015 was extracted. The primary endpoint was disease-specific survival (DSS), and the secondary endpoint was overall survival (OS). The inverse probability of treatment weighting (IPTW) adjustments was used for survival analyses.

resultsOur cohort included 1143 patients. The TPL and CRT groups included 724 and 419 patients, respectively. Following IPTW adjustments, both the OS and DSS of the TPL group were significantly longer than those of the CRT group (P = .02 and P = .002, respectively).

conclusionsSurvival superiority was demonstrated for patients with T4aM0 HPSCC treated with TPL compared with those treated with CRT.

Indexed as

ChemoradiotherapyDatabases, FactualHypopharyngeal NeoplasmsLaryngectomyPharyngectomyAgedCarcinoma, Squamous CellFemaleFollow-Up StudiesHumansJapanMaleMiddle AgedNeoplasm StagingPrognosisSurvival RateChemoradiotherapyHead and Neck Cancer Registry of JapanHypopharyngeal squamous cell carcinomaInverse probability of treatment weighting adjustmentsTotal pharyngolaryngectomy

Identifiers

PMID39133449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.