Evidence map›Paper›PMID 39133386›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025

PPM1F regulates ovarian cancer progression by affecting the dephosphorylation of ITGB1.

Yahui Leng, Zhenzi Luan, Zihang Li, Yongqing Ma, Yang Zhou, Jiaqi Liu, Song Liu, Tian Tian, Wenxiao Feng, Yanni Liu and 24 more

Erratum issuedAbstract read
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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Yahui LengSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Zhenzi LuanSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Zihang LiSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Yongqing MaSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Yang ZhouSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Jiaqi LiuSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Song LiuSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Tian TianSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Wenxiao FengSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Yanni LiuSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Qin ShiSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Chengyang HuangSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Xuan ZhaoThe Second Clinical College, Xi'an Medical University, Xi'an, China.
Wenlong WangSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Ao LiuSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Tianhang WangSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Qiulei RenSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Jiakun LiuSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Qian HuangSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Yaling ZhangSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Bin YinSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Jialin ChenSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Liangliang YangSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Shiyun ZhaoSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Ruoyi BaoSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Xingyu JiSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Yuewen XuSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Liaoyuan LiuSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Junsuo ZhouSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Miao ChenSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Wenhui MaSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Li ShenSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China. shenlihb@163.com.
Te ZhangSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China. 470678192@qq.com.
Hongyan ZhaoSchool of Basic Medicine, Hubei University of Medicine, Shiyan, Hubei, China. zhyzhy62@163.com.ORCID http://orcid.org/0000-0003-2345-5983

Funding

Guiding Project of Hubei Provincial Health Committee WJ2019F065Guiding Project of Shiyan Science and Technology Bureau 22Y19Hubei University of Medicine Talent Start-up Fund 2017QDJZR12Innovation and entrepreneurship training program for college students of Hubei University of Medicine S202210929024Innovation and entrepreneurship training program for college students of Hubei University of Medicine X202210929011Key Program of Hubei Province Education Department Fund D20222101Postdoctoral Natural Science Foundation of Chongqing Science and Technology Bureau cstc2019jcyj-bsh0069Postdoctoral Science Foundation of Jiangsu Province 2020M673560XBThe Advantages Discipline Group (Medicine) Project in Higher Education of Hubei Province 2024XKQY14the Major Program of Hubei Provincial Science Technology Department Fund 2022BCE012The National Natural Science Foundation of China 32001024
6 · The paper itself

Abstract

PPM1F has been shown to play diverse biological functions in the progression of multiple tumors. PPM1F controls the T788/T789 phosphorylation switch of ITGB1 and regulates integrin activity. However, the impacts of PPM1F and ITGB1 on ovarian cancer (OV) progression remain unclear. Whether there is such a regulatory relationship between PPM1F and ITGB1 in ovarian cancer has not been studied. Therefore, the purpose of this study is to elucidate the function and the mechanism of PPM1F in ovarian cancer. The expression level and the survival curve of PPM1F were analyzed by databases. Gain of function and loss of function were applied to explore the function of PPM1F in ovarian cancer. A tumor formation assay in nude mice showed that knockdown of PPM1F inhibited tumor formation. We tested the effect of PPM1F on ITGB1 dephosphorylation in ovarian cancer cells by co-immunoprecipitation and western blotting. Loss of function was applied to investigate the function of ITGB1 in ovarian cancer. ITGB1-mut overexpression promotes the progression of ovarian cancer. Rescue assays showed the promoting effect of ITGB1-wt on ovarian cancer is attenuated due to the dephosphorylation of ITGB1-wt by PPM1F. PPM1F and ITGB1 play an oncogene function in ovarian cancer. PPM1F regulates the phosphorylation of ITGB1, which affects the occurrence and development of ovarian cancer.

Indexed as

Integrin beta1Ovarian NeoplasmsAnimalsCell Line, TumorDisease ProgressionFemaleHumansMiceMice, Inbred BALB CMice, NudePhosphorylationIntegrin beta1Itgb1 protein, humanDephosphorylationITGB1Ovarian cancerPPM1F

Identifiers

PMID39133386

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.