ArticleAging clinical and experimental research2024
Exploring the causal association between frailty index with the common types of arthritis: a Mendelian randomization analysis.
Article in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Frailty Transition and Risk of New-Onset Arthritis Among Adults Aged 45 Years and Older: A Longitudinal Analysis of CHARLS.Healthcare (Basel, Switzerland) · 2026Article
- Association between sex-hormone binding globulin and cardiovascular events in patients with rheumatoid arthritis.Clinical rheumatology · 2026Article
- Changes in frailty and incident risk of degenerative bone and joint diseases and their multimorbidity: a prospective cohort study.Frontiers in public health · 2026Article
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3 authors.
Funding
Abstract
backgroundPrevious observational studies indicated a complex association between frailty and arthritis.
aimsTo investigate the genetic causal relationship between the frailty index and the risk of common arthritis.
methodsWe performed a large-scale Mendelian randomization (MR) analysis to assess frailty index associations with the risk of common arthritis in the UK Biobank (UKB), and the FinnGen Biobank. Summary genome-wide association statistics for frailty, as defined by the frailty index, and common arthritis including rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PSA), and ankylosing spondylitis (AS). The inverse-variance weight (IVW) method served as the primary MR analysis. Heterogeneity testing and sensitivity analysis were also conducted.
resultsOur results denoted a genetic association between the frailty index with an increased risk of OA, the odds ratio (OR)
conclusionThis study demonstrated a potential causal relationship that genetic predisposition to frailty index was associated with the risk of arthritis, especially RA, OA, and PSA, not but AS. Our findings enrich the existing body of knowledge on the subject matter.
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