Evidence map›Paper›PMID 39133301›Full record

ArticleThe Journal of cell biology2024

Histone H4 acetylation differentially modulates proliferation in adult oligodendrocyte progenitors.

David K Dansu, Ipek Selcen, Sami Sauma, Emily Prentice, Dennis Huang, Meng Li, Sarah Moyon, Patrizia Casaccia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David K Dansu *Neuroscience Initiative, Advanced Science Research Center at the City University of New York, New York, NY, USA.ORCID 0000-0003-0342-3060
Ipek Selcen *Neuroscience Initiative, Advanced Science Research Center at the City University of New York, New York, NY, USA.ORCID 0000-0001-7614-1780
Sami SaumaNeuroscience Initiative, Advanced Science Research Center at the City University of New York, New York, NY, USA.ORCID 0000-0001-7278-341X
Emily PrenticeNeuroscience Initiative, Advanced Science Research Center at the City University of New York, New York, NY, USA.ORCID 0009-0000-7192-8226
Dennis HuangNeuroscience Initiative, Advanced Science Research Center at the City University of New York, New York, NY, USA.ORCID 0000-0002-3494-1656
Meng LiNorris Medical Library, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-6063-4855
Sarah MoyonNeuroscience Initiative, Advanced Science Research Center at the City University of New York, New York, NY, USA.ORCID 0000-0002-6142-614X
Patrizia CasacciaNeuroscience Initiative, Advanced Science Research Center at the City University of New York, New York, NY, USA.ORCID 0000-0002-4785-9264

Funding

Environmental Biosensors in the Oligodendrocyte LineageR35NS111604 · NINDS · ADVANCED SCIENCE RESEARCH CENTER · PI Patrizia Casaccia · 2019 to 2026
$9.1M
Acquisition of an Orbitrap Elite Mass Spectrometer with ETDS10OD010582 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI UEBERHEIDE, BEATRIX MAGDALENA · 2013 to 2013
$600k
NIH HHS 1S10OD010582-01A1NIH HHS S10 OD010582NINDS NIH HHS R35 NS111604NINDS NIH HHS R35-NS111604
6 · The paper itself

Abstract

Adult oligodendrocyte progenitors (aOPCs) generate myelinating oligodendrocytes like neonatal progenitors (nOPCs), and they also display unique functional features. Here, using unbiased histone proteomics analysis and ChIP sequencing analysis of PDGFRα+ OPCs sorted from neonatal and adult Pdgfra-H2B-EGFP reporter mice, we identify the activating H4K8ac histone mark as enriched in the aOPCs. We detect increased occupancy of the H4K8ac activating mark at chromatin locations corresponding to genes related to the progenitor state (e.g., Hes5, Gpr17), metabolic processes (e.g., Txnip, Ptdgs), and myelin components (e.g., Cnp, Mog). aOPCs showed higher levels of transcripts related to lipid metabolism and myelin, and lower levels of transcripts related to cell cycle and proliferation compared with nOPCs. In addition, pharmacological inhibition of histone acetylation decreased the expression of the H4K8ac target genes in aOPCs and decreased their proliferation. Overall, this study identifies acetylation of the histone H4K8 as a regulator of the proliferative capacity of aOPCs.

Indexed as

Cell ProliferationHistonesOligodendrocyte Precursor CellsAcetylationAnimalsCell DifferentiationCells, CulturedMiceMice, Inbred C57BLOligodendrogliaHistones

Identifiers

PMID39133301
PMCPMC11318668

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.