ArticleEuropean journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery2024
First-in-men experience with a novel frozen elephant trunk prosthesis featuring an endovascular side branch for left subclavian artery connection.
Article in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Novel branch vessel anastomotic device to rapid link the left subclavian artery in hybrid arch frozen elephant trunk repair.JTCVS techniques · 2026Article
- Frozen elephant trunk for acute type A aortic dissection: long-term outcomes over two decades.European heart journal · 2026Article
- A new branched hybrid arch prosthesis for the frozen elephant trunk procedure.JTCVS techniques · 2026Article
- Total Arch Replacement with a New Hybrid Device to Manage the Left Subclavian Artery in the Frozen Elephant Trunk Technique.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- RapidlinkAnnals of cardiothoracic surgery · 2025Review
- From back table innovation to contemporary application: a review of the frozen elephant trunk technique.Annals of cardiothoracic surgery · 2025Review
- Neck vessels geometry and diameter change in patients with acute type A aortic dissection.General thoracic and cardiovascular surgery · 2025Article
- Management of Non-A Non-B Aortic Dissection: A Narrative Review.Journal of cardiovascular development and disease · 2024Review
- State-of-the-Art Review of Aortic Arch Reconstruction With the Frozen Elephant Trunk.Innovations (Philadelphia, Pa.)Review
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Authors and funding
13 authors.
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Abstract
objectivesThe objective of this study was to enhance the efficiency of aortic arch replacement through the development of a novel frozen elephant trunk (FET) prosthesis with an endovascular side branch for left subclavian artery (LSA) connection. After successful pre-clinical testing, the feasibility and safety of implementing this innovative prosthesis in human subjects were investigated.
methodsBetween September 2020 and September 2021, 4 patients (mean age 67) with conditions such as penetrating ulcer, non A-non B aortic dissection and chronic arch aneurysm underwent surgery utilizing the customized device. Surgeries were performed under high moderate hypothermia (27°C), employing bilateral selective antegrade cerebral perfusion (SACP) and distal aortic perfusion. Anastomosis of the FET prosthesis with the aortic arch occurred in zone 1, followed by separate reimplantation of the left common carotid artery and the brachiocephalic artery.
resultsAll patients were discharged in good clinical condition. The mean aortic cross-clamp, antegrade selective cerebral perfusion and distal aortic perfusion times were 111, 71 and 31 min, respectively. Endovascular extension of the side branch for the LSA was required in all cases to prevent endoleak formation. One patient received a stent graft extension at the end of the operation, while 2 others underwent the procedure during their hospital stay. One patient was diagnosed with an endoleak at the first follow-up after 3 months, and endoleak sealing was achieved via the brachial artery with an extension stent graft.
conclusionsPreliminary clinical outcomes suggest that the newly designed FET prosthesis shows promise in simplifying total arch replacement. These initial findings provide a foundation for planned clinical studies to further assess the effectiveness of this modified surgical hybrid graft, with particular attention to the length and diameter of the LSA sidearm.
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