Evidence map›Paper›PMID 39133170›Full record

ArticleBiology open2024

Membrane structures and functional correlates in the bi-segmented eye lens of the cephalopod.

Justyn W Regini, Naoto Yagi, Robert D Young, Hidetoshi Tanioka, Shigeru Kinoshita, Masato Hoshino, Kentaro Uesugi, Keith M Meek, Andy T Augousti, Carlo Knupp and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Justyn W ReginiStructural Biophysics Group, Cardiff Centre for Vision Science, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, CF24 4HQ, Wales, UK.ORCID 0000-0001-6149-5893
Naoto YagiSPring-8, Japan Synchrotron Radiation Research Institute, 1-1-1, Kouto, Sayo-cho, Sayo-gun, Hyogo, 679-5198Japan.
Robert D YoungStructural Biophysics Group, Cardiff Centre for Vision Science, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, CF24 4HQ, Wales, UK.
Hidetoshi TaniokaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Hirokoji Kawaramachi, Kyoto, 602-0841, Japan.
Shigeru KinoshitaDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Hirokoji Kawaramachi, Kyoto, 602-0841, Japan.ORCID 0000-0002-6839-251X
Masato HoshinoSPring-8, Japan Synchrotron Radiation Research Institute, 1-1-1, Kouto, Sayo-cho, Sayo-gun, Hyogo, 679-5198Japan.
Kentaro UesugiSPring-8, Japan Synchrotron Radiation Research Institute, 1-1-1, Kouto, Sayo-cho, Sayo-gun, Hyogo, 679-5198Japan.
Keith M MeekStructural Biophysics Group, Cardiff Centre for Vision Science, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, CF24 4HQ, Wales, UK.
Andy T AugoustiFaculty of Science, Engineering and Computing, Kingston University London, Friars Avenue, London SW15, UK.
Carlo KnuppStructural Biophysics Group, Cardiff Centre for Vision Science, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, CF24 4HQ, Wales, UK.
Barbara K PierscionekFaculty of Health Medicine and Social Care, Medical Technology Research Centre, Anglia Ruskin University, Bishop Hall Lane, Chelmsford CM1 1SQ, UK.
Andrew J QuantockStructural Biophysics Group, Cardiff Centre for Vision Science, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, CF24 4HQ, Wales, UK.
Gerald F ElliottStructural Biophysics Group, Cardiff Centre for Vision Science, School of Optometry and Vision Sciences, Cardiff University, Maindy Road, Cardiff, CF24 4HQ, Wales, UK.

Funding

Cardiff UniversityFight for Sight 1319/1320Fight for Sight Project Grant 1319/1320Great Britain Sasakawa FoundationSpring-8 beamtime access awardsSpring-8 beamtime access awards,The Great Britain Sasakawa Foundation
6 · The paper itself

Abstract

The cephalopod eye lens is unique because it has evolved as a compound structure with two physiologically distinct segments. However, the detailed ultrastructure of this lens and precise optical role of each segment are far from clear. To help elucidate structure-function relationships in the cephalopod lens, we conducted multiple structural investigations on squid. Synchrotron x-ray scattering and transmission electron microscopy disclose that an extensive network of structural features that resemble cell membrane complexes form a substantial component of both anterior and posterior lens segments. Optically, the segments are distinct, however, and Talbot interferometry indicates that the posterior segment possesses a noticeably higher refractive index gradient. We propose that the hitherto unrecognised network of membrane structures in the cephalopod lens has evolved to act as an essential conduit for the internal passage of ions and other metabolic agents through what is otherwise a highly dense structure owing to a very high protein concentration.

Indexed as

CephalopodaLens, CrystallineAnimalsCell MembraneDecapodiformesMicroscopy, Electron, TransmissionX-Ray DiffractionCell membrane complexesCephalopodEye lens

Identifiers

PMID39133170
PMCPMC11381927

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.