Evidence map›Paper›PMID 39133104›Full record

ReviewJournal of experimental botany2025

Five unaddressed questions about cytokinin biosynthesis.

Hitoshi Sakakibara

Abstract readReview
In one paragraph

Review in Journal of experimental botany, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Hitoshi SakakibaraGraduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan.ORCID 0000-0001-5449-6492

Funding

Japan Society for the Promotion of Science, Japan
6 · The paper itself

Abstract

Cytokinins, a class of phytohormones, play crucial roles in regulating plant growth and stress responses through finely tuned feedback loops involving metabolic and signaling cascades. Over the past 25 years, studies have identified key genes involved in cytokinin biosynthesis and inactivation pathways. Nevertheless, several gaps remain in our understanding, particularly regarding the movement of intermediate metabolites between subcellular compartments and the discrepancy between the products of adenosine phosphate-isopentenyltransferase (IPT) and the substrate preferences of subsequent reactions. Recent gene discoveries related to lonely guy (LOG)-independent pathways suggest a spatial extension of cytokinin biosynthesis into the apoplast. Other intriguing issues remain to be addressed, such as elucidating the synthetic pathway for cis-zeatin and unraveling the molecular mechanisms governing selective substrate use by the cytokinin biosynthetic enzyme Tumor morphology root (Tmr) from the phytopathogen Agrobacterium tumefaciens. Further studies are needed to reveal a fully comprehensive picture of cytokinin metabolism.

Indexed as

CytokininsPlant Growth RegulatorsPlantsAlkyl and Aryl TransferasesAlkyl and Aryl TransferasesCytokininsPlant Growth RegulatorsAgrobacterium tumefaciensArabidopsis thalianabiosynthesiscis-zeatincrown gallcytokininmetabolismOryza sativaplant hormonetrans-zeatin

Identifiers

PMID39133104
PMCPMC12066119

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.