ArticleEuropean journal of neurology2024
Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia.
Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The trial behind it
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Who cites it
2 citing papers in PubMed.
- Layer-Specific Colocalization of Microglia with Amyloid Plaques in the Middle Temporal Gyrus Predicts Cognitive Decline in Alzheimer's Disease.Aging and disease · 2025Article
- Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia.European journal of neurology · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
background and purposeThis study evaluated associations of brain amyloid with 2-year objective and subjective cognitive measures in a trial-ready older general population at risk for dementia.
methodsForty-eight participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability underwent
resultsMean age was 71.4 ± 5.06 years, and 20 participants (42%) had positive baseline PiB-PET scans. Amyloid positivity was associated with lower NTB executive function at baseline and less favorable 2-year NTB total score and memory trajectories, but not with other objective or subjective cognitive measures. Overall, there was little cognitive decline during 2 years.
conclusionsAmyloid accumulation may affect objective but not necessarily subjective cognition from a very early at-risk stage, although substantial decline likely requires >2 years to occur.
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