Evidence map›Paper›PMID 39132765›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Air pollution amyloidogenesis is attenuated by the gamma-secretase modulator GSM-15606.

Jose A Godoy-Lugo, Max A Thorwald, Mafalda Cacciottolo, Carla D'Agostino, Ararat Chakhoyan, Constantinos Sioutas, Rudolph E Tanzi, Kevin D Rynearson, Caleb E Finch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Air pollution amyloidogenesis is attenuated by the gamma-secretase modulator GSM-15606.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jose A Godoy-LugoLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Max A ThorwaldLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Mafalda CacciottoloLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Carla D'AgostinoLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Ararat ChakhoyanDepartment of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Constantinos SioutasCivil and Environmental Engineering, University of Southern California, Los Angeles, California, USA.
Rudolph E TanziDepartment of Neurology, Genetics and Aging Research Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA.
Kevin D RynearsonDepartment of Neurosciences, University of California San Diego, La Jolla, California, USA.
Caleb E FinchLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.

Funding

VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUI, HELENA CHANG · 1985 to 2019
$41.0M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2018 to 2022
$11.5M
Amyloid and inflammation: modulation by apoE, gender, air pollution, and drugsRF1AG051521 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, CALEB E · 2015 to 2015
$3.0M
CEF from the Cure Alzheimer's Fund and NIH P01-AG055367CEF from the Cure Alzheimer's Fund and NIH P50-AG05142CEF from the Cure Alzheimer's Fund and NIH R01-AG051521NIA NIH HHS P01 AG055367NIA NIH HHS P50 AG005142NIA NIH HHS RF1 AG051521
6 · The paper itself

Abstract

introductionChronic air pollution (AirPoll) is associated with accelerated cognitive decline and risk of Alzheimer's disease (AD). Correspondingly, wild-type and AD-transgenic rodents exposed to AirPoll have increased amyloid peptides and behavioral impairments.

methodsWe examined the γ-secretase modulator GSM-15606 for potential AirPoll protection by its attenuating of amyloid beta (Aβ)42 peptide production. Male and female wild-type mice were fed GSM-15606 during an 8-week inhalation exposure to AirPoll subfractions, ambient nanoparticulate matter (nPM), and diesel exhaust particles (DEP).

resultsGSM-15606 decreased Aβ42 during nPM and DEP exposure without changing beta- or gamma-secretase activity or BACE1 and PS1 protein levels. DEP increased lateral ventricle volume by 25%. DISCUSSION: These enzyme responses are relevant to AD drug treatments, as well as to the physiological functions of the Aβ42 peptide. GSM-15606 attenuation of Aβ42 may benefit human exposure to AirPoll. HIGHLIGHTS: Gamma-secretase modulator (GSM-15606) attenuates the amyloidogenic amyloid beta (Aβ)42 peptide during exposure to air pollution, which may be a mechanism by which air pollution increases Alzheimer's disease (AD) risk. AD drug treatments may also consider Aβ homeostasis among the chronic effects of GSM-15606 and other amyloid reduction treatments on secretase enzymes.

Indexed as

Air PollutionAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAlzheimer DiseaseAnimalsAspartic Acid EndopeptidasesDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLPeptide FragmentsVehicle EmissionsAmyloid beta-Peptidesamyloid beta-protein (1-42)Amyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesPeptide FragmentsVehicle EmissionsAirPollair pollutionamyloid attenuationdiesel exhaust particlesgamma‐secretase modulatorGSM‐15606nanoparticulate matter

Identifiers

PMID39132765
PMCPMC11497728

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.