Evidence map›Paper›PMID 39132621›Full record

ArticleGastro hep advances2023

Regulation of Parietal Cell Homeostasis by Bone Morphogenetic Protein Signaling.

Hidehiko Takabayashi, Tuo Ji, Lei Peng, Xuan Li, Masahiko Shinohara, Maria Mao, Kathryn A Eaton, Yatrik M Shah, Andrea Todisco

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gastro hep advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hidehiko TakabayashiDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Tuo JiDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Lei PengDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Xuan LiDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Masahiko ShinoharaDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Maria MaoDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Kathryn A EatonDepartment of Microbiology and Immunology, University of Michigan Medical Center, Ann Arbor, Michigan.
Yatrik M ShahDepartment of Molecular and Integrative Physiology, University of Michigan Medical Center, Ann Arbor, Michigan.
Andrea TodiscoDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
Control of iron absorption by intestinal HIF2 in iron and hematological disordersR01DK095201 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2012 to 2025
$5.7M
The role of HIF2alpha in colon carcinogenesisR01CA148828 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2010 to 2025
$5.2M
Understanding the mechanisms of iron addiction in colon cancerR01CA245546 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHAH, YATRIK M · 2020 to 2024
$2.3M
Regulation of gastric metaplasia, dysplasia and neoplasia by Bone Morphogenetic Protein signalingR01DK121785 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TODISCO, ANDREA · 2020 to 2023
$1.8M
NCI NIH HHS R01 CA148828NCI NIH HHS R01 CA245546NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK095201NIDDK NIH HHS R01 DK121785
6 · The paper itself

Abstract

Background and Aims: Loss of bone morphogenetic protein (BMP) signaling in the stomach, achieved by transgenic expression of the BMP inhibitor noggin ( Methods: Mice with floxed alleles of BMP receptor 1a ( Results: Six-month-old Conclusion: PC-specific loss of BMP signaling alters the homeostasis of the gastric epithelium leading to the development of metaplasia.

Indexed as

DifferentiationDysplasiaMetaplasiaRNA-Seq

Identifiers

PMID39132621
PMCPMC11307507

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.