Evidence map›Paper›PMID 39132618›Full record

ArticleGastro hep advances2023

It Is Time for a Simplified Approach to Hepatitis B Elimination.

Douglas Dieterich, Camilla Graham, Su Wang, Paul Kwo, Young-Suk Lim, Chun-Jen Liu, Kosh Agarwal, Mark Sulkowski

Erratum issuedAbstract read
In one paragraph

Article in Gastro hep advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Time for a globally unified chronic HBV terminology?JHEP reports : innovation in hepatology · 2025
    Review
  5. Review
  6. Article
  7. Progress towards "The Treat-All Approach" for hepatitis B.Translational gastroenterology and hepatology · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. [Chronic hepatitis B: from "treat only if" to "treat all"].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Douglas DieterichDivision of Liver Disease, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Camilla GrahamDivision of Infectious Disease, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Su WangCenter for Asian Health, Saint Barnabas Medical Center, RWJ Barnabas Health, Florham Park, New Jersey.
Paul KwoDepartment of Gastroenterology and Hepatology, Stanford Medical Center, Pleasanton, California.
Young-Suk LimDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Chun-Jen LiuDepartment of Internal Medicine and Hepatitis Research Center at the National Taiwan University Hospital, Taipei, Taiwan.
Kosh AgarwalInstitute of Liver Studies, King's College Hospital NHS Foundation Trust, London, England.
Mark SulkowskiDivision of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Hepatitis B virus (HBV) infection continues to threaten millions of lives across the globe, despite universal vaccination efforts. Current guidelines for screening, vaccination, and treatment are complex and have left too many people undiagnosed or improperly managed. Antiviral therapy has been shown to significantly reduce the incidence of liver-related complications, including liver cancer. However, the complexity of existing guidelines can make it difficult to identify which patients to target for treatment, and recommendations that are difficult to implement in real-world settings pose a barrier to eligible patients to receive therapy and contribute to health disparities in HBV care. The goal of this global expert panel was to gain consensus on a streamlined approach to HBV care to facilitate implementation of HBV intervention and treatment, especially in the primary care setting. Methods: A group of 8 liver and infectious disease specialists attended a meeting in January 2021 with the objective of gaining consensus on a streamlined algorithm for HBV care that would encourage implementation of HBV intervention and treatment. Results: We have created a comprehensive perspective highlighting screening optimization, diagnostic workup, treatment, and monitoring. This treatment algorithm is designed to provide a streamlined visual pathway for risk stratification and management of patients with HBV that can be adapted in various care settings. Conclusion: Simplification of guidelines will be critical to achieving health equity to address this public health threat and achieve HBV elimination.

Indexed as

HBV algorithmHepatitis BSimplified treatment

Identifiers

PMID39132618
PMCPMC11307636

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.