ReviewJournal of the Society for Cardiovascular Angiography & Interventions
Incidence of Mortality and Complications in High-Risk Pulmonary Embolism: A Systematic Review and Meta-Analysis.
Review in Journal of the Society for Cardiovascular Angiography & Interventions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04795167 (FlowTriever for Acute Massive Pulmonary Embolism), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
FlowTriever for Acute Massive Pulmonary Embolism (FLAME)
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Catheter-Directed Mechanical Thrombectomy without Thrombolysis for Intermediate-to-High-Risk Acute Pulmonary Embolism: A Systematic Review and Meta-Analysis.Cardiovascular and interventional radiology · 2026Pooled it
- Outcomes of Venous-Arterial Extracorporeal Membrane Oxygenation Therapy in Acute Pulmonary Embolism: A Single-Center Experience.Journal of thrombosis and thrombolysis · 2026Article
- Reperfusion Therapy and Outcomes in High-Risk Pulmonary Embolism: Multicenter Registry Study From the Tokyo Cardiovascular Care Unit Network.Circulation reports · 2026Article
- Vacuum-Assisted Percutaneous Management of Cardiac Implantable Electronic Device Lead Endocarditis.Journal of clinical medicine · 2026Review
- CIRSE Standards of Practice on Endovascular Treatment of Acute Pulmonary Embolism.Cardiovascular and interventional radiology · 2026Article
- Changes in Arterial-Alveolar Oxygen Gradient and Mixed Venous Oxygen Saturations in Mechanical Thrombectomy for Pulmonary Embolism: A Prospective Cohort Study.Pulmonary circulation · 2026Article
- Point-of-care ultrasound in hemodynamically unstable pulmonary embolism.Critical care (London, England) · 2026Review
- Association Between ABO Blood Group, COVID-19 Status, and Early Respiratory Outcomes in Acute Pulmonary Embolism: An Interaction Analysis.Journal of cardiovascular development and disease · 2026Article
- Diagnoses of pulmonary embolism from non-contrast 4DCT using image processing-derived quantitative perfusion scores.npj biomedical innovations · 2026Article
- Outcome of Patients Presenting With High-Risk Pulmonary Embolism Treated With Mechanical Thrombectomy: A Subgroup Analysis From the STRIKE-PE Study.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Personalised viscoelastometry-guided systemic thrombolysis for high- and intermediate-high-risk acute pulmonary embolism in the ICU: a single-centre randomised controlled interventional feasibility trial.Intensive care medicine experimental · 2026Article
- Prognostic Value of Arterial Lactate in Predicting In-Hospital Mortality in Acute Pulmonary Embolism.Diagnostics (Basel, Switzerland) · 2026Article
- Risk stratification in pulmonary embolism: current evidence and future directions.The Journal of cardiovascular surgery · 2026Review
- Mechanical thrombectomy for massive PE with incidental discovery of a patent foramen ovale: a case report.CVIR endovascular · 2026Article
- Contemporary national trends in the management of admissions for pulmonary embolism.Frontiers in cardiovascular medicine · 2026Article
- VA-ECMO in high-risk pulmonary embolism: outcomes and role as bridge to recovery.Resuscitation plus · 2026Article
- CIRSE Standards of Practice on Endovascular Treatment of Acute Pulmonary Embolism.Cardiovascular and interventional radiology · 2025Article
- Pathophysiology and management of right ventricular failure in critically ill patients: A narrative review.World journal of critical care medicine · 2025Review
- Advancements in Pulmonary Embolism Management: Current Approaches and Future Directions.Reviews in cardiovascular medicine · 2025Review
- Gender disparities in high-risk pulmonary embolism: a nationwide analysis of management strategies and clinical outcomes.BMC cardiovascular disorders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The relationship between the early hemodynamic consequences of acute pulmonary embolism (PE) and short-term morbidity and mortality has long been recognized. The mortality incidence and other complications after high-risk (massive) PE, the most severe category of the disease, are summarized in this meta-analysis. Methods: A systematic review and meta-analysis of studies reporting on patients with massive PE indexed by PubMed and the Cochrane Library over a 10-year period (2010-2020) was conducted. Studies with adequate information to specify a cohort of patients with high-risk PE defined by the American Heart Association and European Society of Cardiology criteria and their clinical outcomes were included. Incidences were calculated as weighted averages with 95% CIs. Results: A total of 27 publications spanning 1517 patients were identified that met the search criteria for high-risk PE. In-hospital all-cause mortality averaged 28.3% (95% CI, 20.9%-37.0%) in patients at high risk, comparable to the 30-day all-cause mortality of 30.2% (95% CI, 22.3%-39.6%). In-hospital major bleeding was 13.8% (95% CI, 9.3%-20.0%), and intracranial hemorrhage was reported in 3.6% (95% CI, 2.2%-5.9%). The risk of bias in publications was graded as low-to-moderate, with substantial heterogeneity among the studies. Conclusions: This systematic review and meta-analysis provided low-quality to moderate-quality evidence documenting mortality, major bleeding, and other complications in patients meeting the American Heart Association and European Society of Cardiology criteria for high-risk PE. This information was used to inform the design of the FLowTriever for Acute Massive Pulmonary Embolism (FLAME) study (NCT04795167), a study evaluating an advanced therapy for patients with high-risk PE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.