Evidence map›Paper›PMID 39132489›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Genetic associations with human longevity are enriched for oncogenic genes.

Junyoung Park, Andrés Peña-Tauber, Lia Talozzi, Michael D Greicius, Yann Le Guen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Junyoung ParkDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0002-9098-2858
Andrés Peña-TauberDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
Lia TalozziDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0003-1827-0407
Michael D GreiciusDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0002-5462-9037
Yann Le GuenQuantitative Sciences Unit, Department of Medicine, Stanford University, Stanford, CA, 94304, USA.ORCID 0000-0001-6649-8364

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI MICHAEL KENNEY · 2007 to 2026
$71.4M
Stanford Center for Clinical and Translational Research and EducationUM1TR004921 · NCATS · STANFORD UNIVERSITY · PI MANISHA DESAI, DEAN W FELSHER · 2024 to 2026
$30.1M
NCATS NIH HHS UM1 TR004921NCI NIH HHS P30 CA124435
6 · The paper itself

Abstract

Human lifespan is shaped by both genetic and environmental exposures and their interaction. To enable precision health, it is essential to understand how genetic variants contribute to earlier death or prolonged survival. In this study, we tested the association of common genetic variants and the burden of rare non-synonymous variants in a survival analysis, using age-at-death (N = 35,551, median [min, max] = 72.4 [40.9, 85.2]), and last-known-age (N = 358,282, median [min, max] = 71.9 [52.6, 88.7]), in European ancestry participants of the UK Biobank. The associations we identified seemed predominantly driven by cancer, likely due to the age range of the cohort. Common variant analysis highlighted three longevity-associated loci:

Identifiers

PMID39132489
PMCPMC11312667

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.