Evidence map›Paper›PMID 39132479›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Genomic epidemiology reveals 2022 mpox epidemic in New York City governed by heavy-tailed sexual contact networks.

Jonathan E Pekar, Yu Wang, Jade C Wang, Yucai Shao, Faten Taki, Lisa A Forgione, Helly Amin, Tyler Clabby, Kimberly Johnson, Lucia V Torian and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jonathan E PekarBioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, CA 92093, USA.
Yu WangDepartment of Computer Science and Engineering, University of California San Diego, La Jolla, CA 92093, USA.
Jade C WangNew York City Department of Health and Mental Hygiene, Public Health Laboratory, New York, NY 11101, USA.
Yucai ShaoDepartment of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA.
Faten TakiNew York City Department of Health and Mental Hygiene, Public Health Laboratory, New York, NY 11101, USA.
Lisa A ForgioneNew York City Department of Health and Mental Hygiene, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, Long Island City, NY 11101, USA.
Helly AminNew York City Department of Health and Mental Hygiene, Public Health Laboratory, New York, NY 11101, USA.
Tyler ClabbyNew York City Department of Health and Mental Hygiene, Public Health Laboratory, New York, NY 11101, USA.
Kimberly JohnsonNew York City Department of Health and Mental Hygiene, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, Long Island City, NY 11101, USA.
Lucia V TorianNew York City Department of Health and Mental Hygiene, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, Long Island City, NY 11101, USA.
Sarah L BraunsteinNew York City Department of Health and Mental Hygiene, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, Long Island City, NY 11101, USA.
Preeti PathelaNew York City Department of Health and Mental Hygiene, Bureau of Hepatitis, HIV, and Sexually Transmitted Infections, Long Island City, NY 11101, USA.
Enoma OmoregieNew York City Department of Health and Mental Hygiene, Public Health Laboratory, New York, NY 11101, USA.
Scott HughesNew York City Department of Health and Mental Hygiene, Public Health Laboratory, New York, NY 11101, USA.
Marc A SuchardDepartment of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA 90095, USA.
Tetyana I VasylyevaDepartment of Population Health and Disease Prevention, University of California Irvine, Irvine, CA 92617, USA.
Philippe LemeyDepartment of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory for Clinical and Epidemiological Virology, KU Leuven, Leuven, Belgium.
Joel O WertheimDepartment of Medicine, University of California San Diego, La Jolla, CA 92093, USA.

Funding

Automation and Evaluation of Real-Time Transmission Network-Based HIV Prevention Services in New York CityR01AI135992 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WERTHEIM, JOEL OKRENT · 2018 to 2022
$3.6M
Statistical Innovation to Integrate Sequences and Phenotypes for Scalable Phylodynamic InferenceR01AI153044 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Marc A. Suchard · 2021 to 2026
$2.4M
NIAID NIH HHS R01 AI135992NIAID NIH HHS R01 AI153044
6 · The paper itself

Abstract

The global mpox epidemic in 2022 was likely caused by transmission of mpox virus (MPXV) through sexual contact networks, with New York City (NYC) experiencing the first and largest outbreak in the United States. By performing a phylogeographic and epidemiological analysis of MPXV, we identify at least 200 introductions of MPXV into NYC and 84 leading to onward transmission. Through a comparative analysis with human immunodeficiency virus (HIV) in NYC, we find that both MPXV and HIV genomic cluster sizes are best fit by scale-free distributions and that people in MPXV clusters are more likely to have previously received an HIV diagnosis (odds ratio=1.58;

Identifiers

PMID39132479
PMCPMC11312668

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.