ReviewJournal of the Society for Cardiovascular Angiography & Interventions
Management of Peripheral Arterial Disease: Lifestyle Modifications and Medical Therapies.
Review in Journal of the Society for Cardiovascular Angiography & Interventions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Understanding the Pain Experience and Treatment Considerations Along the Spectrum of Peripheral Artery Disease: A Scientific Statement From the American Heart Association.Circulation. Cardiovascular quality and outcomes · 2025Guideline
- Efficacy and safety of rivaroxaban plus aspirin compared with aspirin alone in patients with peripheral arterial disease: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2026Article
- The Equality Health-CVD intervention: protocol for a feasibility study of a home-based multi-component cardiovascular support intervention.Pilot and feasibility studies · 2026Article
- Global, regional, and national burden of lower extremity peripheral arterial disease: a systematic analysis of prevalence, incidence, deaths, and dalys from 1990 to 2021 with projections and dietary risk factors to 2036.Journal of health, population, and nutrition · 2025Article
- Peripheral artery disease.Nature reviews. Disease primers · 2025Review
- Does Genotype Affect the Efficacy of PCSK9 Inhibitors in the Treatment of Familial Hypercholesterolemia?Cardiovascular drugs and therapy · 2025Review
- Acute Pain Management in Peripheral Artery Disease: A Holistic, Beyond-Opioids, Individualized Multimodal Approach.Turkish journal of anaesthesiology and reanimation · 2024Review
- Advancements in textile techniques for cardiovascular tissue replacement and repair.APL bioengineering · 2024Review
- Safety and Efficacy of Combined Coronary and Peripheral Percutaneous Revascularization: A Proof-of-Concept Study.Journal of clinical medicine · 2024Article
- Association between oxidative balance scores and peripheral artery disease in US adults: a cross-sectional study.Frontiers in nutrition · 2024Article
- Cost-Effectiveness of Exercise Therapy in Patients with Intermittent Claudication-A Comparison of Supervised Exercise, Home-Based Structured Exercise, and Walk Advice from the SUNFIT Trial.Journal of clinical medicine · 2023Article
- Antithrombotic Therapy in Peripheral Artery Disease: Current Evidence and Future Directions.Journal of cardiovascular development and disease · 2023Review
- Trends and Potential Risk Factors of Lower Extremity Peripheral Arterial Disease: Results from the Global Burden of Disease Study 2021.Pulse (Basel, Switzerland)Article
- The Effect of Vitamin D Supplementation on Ankle-brachial Index in Patients with Type 2 Diabetes: A Randomized Clinical Trial.Iranian journal of nursing and midwifery researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral artery disease (PAD) commonly refers to atherosclerotic narrowing of noncoronary arteries, primarily those supplying the lower extremities. The risk factors for PAD include smoking, hyperlipidemia, hypertension, and diabetes mellitus. Patients with PAD are at a heightened risk of major adverse cardiovascular events (including myocardial infarction, stroke, and cardiovascular death) and major adverse limb events (including progressive symptoms or limb ischemia requiring peripheral revascularization, amputation, and acute limb ischemia), highlighting the need for guideline-directed therapies. Lifestyle modifications and medical therapies are utilized to improve function and outcomes in this patient population. Adherence to a healthy diet and smoking cessation are both associated with better outcomes in patients with PAD. Medical therapies targeting axes of risk, including lipid-modifying therapies, antithrombotic therapies, and targeted diabetes therapies, are available to reduce this risk in patients with PAD; however, significant residual risk remains. Unfortunately, despite guideline recommendations and efforts at education, even available medical therapies remain underutilized in patients with PAD. Continued development of novel therapies and efforts to improve the provision of care in patients with PAD are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.