Evidence map›Paper›PMID 39132339›Full record

ReviewJournal of the Society for Cardiovascular Angiography & Interventions

Impact of Intramyocardial Hemorrhage on Clinical Outcomes in ST-Elevation Myocardial Infarction: A Systematic Review and Meta-analysis.

Rohit Vyas, Khalid H Changal, Sapan Bhuta, Vanessa Pasadyn, Konrad Katterle, Matthew J Niedoba, Keyur Vora, Rohan Dharmakumar, Rajesh Gupta

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of the Society for Cardiovascular Angiography & Interventions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06851325 (Antiplatelets and Hemorrhagic MI), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06851325 completednot on this map

Antiplatelets and Hemorrhagic MI

TypeobservationalSponsorRohan DharmakumarRan2023 to 2025Enrolled6,180ConditionsSTEMI, Acute Myocardial Infarction
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Reperfusion injury in STEMI: a double-edged sword.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rohit VyasDivision of Cardiovascular Medicine, University of Toledo, Toledo, Ohio.
Khalid H ChangalDivision of Cardiovascular Medicine, University of Toledo, Toledo, Ohio.
Sapan BhutaDepartment of Internal Medicine, University of Toledo, Toledo, Ohio.
Vanessa PasadynDepartment of Internal Medicine, University of Toledo, Toledo, Ohio.
Konrad KatterleDepartment of Internal Medicine, University of Toledo, Toledo, Ohio.
Matthew J NiedobaDepartment of Internal Medicine, University of Toledo, Toledo, Ohio.
Keyur VoraDepartment of Medicine and Cardiovascular Institute, Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, Indiana.
Rohan DharmakumarDepartment of Medicine and Cardiovascular Institute, Krannert Cardiovascular Research Center, Indiana University School of Medicine, Indianapolis, Indiana.
Rajesh GuptaDivision of Cardiovascular Medicine, University of Toledo, Toledo, Ohio.

Funding

Developing a MRI-guided Disease-Modifying Therapy for Post Infarction Chronic Heart FailureR01HL133407 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Rohan Dharmakumar · 2017 to 2026
$4.9M
An Accurate Non-Contrast-Enhanced Cardiac MRI Method for Imaging Chronic Myocardial Infarctions: Technical Developments to Rapid Clinical ValidationR01HL136578 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2017 to 2020
$3.4M
Mechanistic Insights to A Translatable Therapy for Acute Reperfused Hemorrhagic Myocardial InfarctionsR01HL147133 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI DHARMAKUMAR, ROHAN, FRANCIS, JOSEPH · 2020 to 2023
$3.2M
Accurate, Needle-Free, MRI-based Detection of Ischemic Heart Disease without Contrast AgentsR01HL148788 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI DHARMAKUMAR, ROHAN · 2020 to 2023
$3.0M
NHLBI NIH HHS R01 HL133407NHLBI NIH HHS R01 HL136578NHLBI NIH HHS R01 HL147133NHLBI NIH HHS R01 HL148788
6 · The paper itself

Abstract

Background: Intramyocardial hemorrhage (IMH) occurs after ST-elevation myocardial infarction (STEMI) and has been documented using cardiac magnetic resonance imaging. The prevalence and prognostic significance of IMH are not well described, and the small sample size has limited prior studies. Methods: We performed a comprehensive literature search of multiple databases to identify studies that compared outcomes in STEMI patients with or without IMH. The outcomes studied were major adverse cardiovascular events (MACE), infarct size, thrombolysis in myocardial infarction (TIMI) flow after percutaneous coronary intervention (PCI), left ventricular end-diastolic volume (LVEDV), left ventricular ejection fraction (LVEF), and mortality. Odds ratios (ORs) and standardized mean differences with corresponding 95% CIs were calculated using a random effects model. Results: Eighteen studies, including 2824 patients who experienced STEMI (1078 with IMH and 1746 without IMH), were included. The average prevalence of IMH was 39%. There is a significant association between IMH and subsequent MACE (OR, 2.63; 95% CI, 1.79-3.86; Conclusions: Intramyocardial hemorrhage is prevalent in approximately 40% of patients who experience STEMI. IMH is a significant predictor of MACE and is associated with larger infarct size, higher LVEDV, and lower LVEF after STEMI.

Indexed as

adverse remodelingintramyocardial hemorrhageMACEmicrovascular obstructionmyocardial infarctionSTEMI

Identifiers

PMID39132339
PMCPMC11307811

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.