ArticleFrontiers in psychiatry2024
Obstructive sleep apnea and 19 gastrointestinal diseases: a Mendelian randomization study.
Article in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Association of Obstructive Sleep Apnea and Postoperative Complications in Bariatric Surgery: How Crucial is Preoperative CPAP Compliance?Obesity surgery · 2026Article
- Article
- Causal Associations of Obstructive Sleep Apnea With Cancer Risk: A Mendelian Randomization Study.Brain and behavior · 2025Article
- Risk of Biliary Tract and Pancreatic Cancer Following Obstructive Sleep Apnea Diagnosis: Analysis of a National Health Insurance Database.Journal of rhinology : official journal of the Korean Rhinologic Society · 2025Article
- Impaired sleep efficiency predicts adverse prognosis in elderly pancreatic cancer patients: a retrospective case - control study based on wearable smart devices.American journal of translational research · 2025Article
- Association Between Obstructive Sleep Apnea and Reflux Disease: A Systematic Review and Meta-Analysis.Nature and science of sleep · 2025Review
- Depressive symptoms mediate the association between sleep disorders and gallstone disease: a causal mediation analysis of NHANES 2017-2020.Frontiers in psychiatry · 2025Article
- The Importance of Genetic Screening on the Syndromes of Colorectal Cancer and Gastric Cancer: A 2024 Update.Biomedicines · 2024Review
- Investigating the causal links between obstructive sleep apnea and gastrointestinal diseases mediated by metabolic syndrome through mendelian randomization.Scientific reports · 2024Article
- Obstructive sleep apnea, CPAP therapy, and gastroesophageal reflux symptoms: evidence from a prospective cohort study.Frontiers in neurologyArticle
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Authors and funding
8 authors.
Funding
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Abstract
Background: Alterations gastrointestinal diseases (GDs) were reported in individuals with obstructive sleep apnea (OSA), however, the genetic background between OSA and GDs is still unclear. Methods: This investigation employed Mendelian randomization (MR) analyses to evaluate the causal effect between OSA and 19 types of GDs (gastroesophageal reflux disease (GERD), ulcerative colitis, celiac disease, Crohn's disease, chronic gastritis, irritable bowel syndrome, primary biliary cholangitis, diverticular disease, gastroduodenal ulcer, acute pancreatitis, non-alcoholic fatty liver disease, primary sclerosing cholangitis, cirrhosis, calculus of bile duct, calculus of gallbladder, pancreatic cancer, gastric cancer, colorectal cancer, and esophageal cancer). The inverse-variance weighted (IVW) method was used to evaluate the main effects model of causality. Results: This MR study suggests that OSA may play a causal role inflammation-related GDs (GERD, P Conclusion: This MR analysis provides compelling evidence of an independent causal relationship between genetically predicted OSA and an elevated risk of inflammation-related GDs. Besides, no causal association was observed between OSA and cancers. Further studies should be carried out to verify our findings.
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