Evidence map›Paper›PMID 39132193›Full record

ArticleToxicology research2024

Toxicological evaluation of copper oxide nanoparticles following their intraperitoneal injection to Wistar rats.

Nisha Shareef, Shairyar Abid, Aqsa Amir, Amir Ismail, Abd Ullah, Adnan Ahmad, Samir Ibenmoussa, Yousef A Bin Jardan, Mohammed Bourhia, Ather Ibrahim and 1 more

Abstract read
In one paragraph

Article in Toxicology research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nisha ShareefInstitute of Advanced Materials, Bahauddin Zakariya University, Multan 60800, Pakistan.
Shairyar AbidInstitute of Advanced Materials, Bahauddin Zakariya University, Multan 60800, Pakistan.
Aqsa AmirInstitute of Advanced Materials, Bahauddin Zakariya University, Multan 60800, Pakistan.
Amir IsmailInstitute of Food Sciences and Nutrition, Bahauddin Zakariya University, Multan 60800, Pakistan.
Abd UllahDepartment of Zoology, Shaheed Benazir Butto University, Upper Dir 18050, Pakistan.
Adnan AhmadDepartment of Zoology, Shaheed Benazir Butto University, Upper Dir 18050, Pakistan.
Samir IbenmoussaLaboratory of Therapeutic and Organic Chemistry, Faculty of Pharmacy, University of Montpellier, Montpellier 34000, France.
Yousef A Bin JardanDepartment of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 11451, Riyadh 11451, Saudi Arabia.
Mohammed BourhiaDepartment of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy, Ibn Zohr University, Laayoune 70000, Morocco.
Ather IbrahimInstitute of Advanced Materials, Bahauddin Zakariya University, Multan 60800, Pakistan.
Furhan IqbalInstitute of Zoology, Bahauddin Zakariya University, Multan 60800, Pakistan.ORCID https://orcid.org/0000-0003-4996-0152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Copper oxide (Cu Methods: For 14 consecutive days, Wistar rats (6 weeks old) of both sexes were intraperitoneally injected with 10 mg/mL saline/Kg body weight of CO NPs, while the control groups intraperitoneally received saline solution for same duration. Behavioral tests (open field and novel object recognition), complete blood count, selected biomarkers of oxidative stress and Copper concentration in brain and liver were determined in all subjects. Results: High mortality rates [male 40% and female 60%] were observed in rats exposed to CO NPs. A sever decrease in body weight was also observed in both male and female rats exposed to CO NPs. Female rats treated with CO NPs spent significantly more time with novel object as compared to control [ Conclusion: In conclusion, we are reporting that intraperitoneal injections of CO NPs for 14 days can disturb complete blood count and biomarkers of oxidative stress in lungs of Wistar rats.

Indexed as

behaviorbiomarkers of oxidative stressblood chemistryCu2O NPsWistar rat

Identifiers

PMID39132193
PMCPMC11306316

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.