Evidence map›Paper›PMID 39132094›Full record

ArticleDrug discovery today. Disease models2016

Genome Wide Conditional Mouse Knockout Resources.

C Kaloff, K Anastassiadis, A Ayadi, R Baldock, J Beig, M-C Birling, A Bradley, S Brown, A Bürger, W Bushell and 56 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug discovery today. Disease models, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

66 authors.

C KaloffInstitute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
K AnastassiadisBiotechnology Center (BIOTEC) of the Technische Universität Dresden, 01307 Dresden, Germany.
A AyadiCELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404 Illkirch-Graffenstaden, France.
R BaldockMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, College of Medicine and Veterinary Medicine, Edinburgh, Scotland EH4 2XU, UK.
J BeigInstitute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
M-C BirlingCELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404 Illkirch-Graffenstaden, France.
A BradleyThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
S BrownMammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX110RD, UK.
A BürgerInstitute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
W BushellThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
F ChianiIstituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche (CNR), Monterotondo-Scalo, I-00015 Rome, Italy.
F S CollinsOffice of the Director, National Institutes of Health, Bethesda, Maryland, 20892, USA.
B DoeThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
J T EppigThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
R H FinnelThe Texas A&M Institute for Genomic Medicine, College Station, Texas, 77843-4485 USA; University of Texas at Austin, Austin, Texas, 78712, USA.
C FletcherNational Institutes of Health, Bethesda, Maryland, 20205, USA.
P FlicekEuropean Bioinformatics Institute (EBI), Hinxton, Cambridge, CB101ST, UK.
M FrayMammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX110RD, UK.
R H FriedelInstitute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
A GambadoroIstituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche (CNR), Monterotondo-Scalo, I-00015 Rome, Italy.
H GatesMammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX110RD, UK.
J HansenInstitute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
Y HeraultInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France.
G G HicksUniversity of Manitoba, Manitoba Institute of Cell Biology, Winnipeg, MB, R3EOV9, Canada.
A HörleinInstitute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
M Hrabé de AngelisInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
V IyerThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
P J de JongChildren's Hospital Oakland Research Institute, CHORI, Oakland, CA, 94609, USA.
G KoscielnyEuropean Bioinformatics Institute (EBI), Hinxton, Cambridge, CB101ST, UK.
R KühnInstitute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
P LiuThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
K C LloydMouse Biology Program, School of Veterinary Medicine, University of California, Davis, California 95616, USA.
R G LopezInstituto de Neurociencias (UMH-CSIC), San Juan de Alicante.
S MarschallInstitute of Experimental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
S MartínezInstituto de Neurociencias (UMH-CSIC), San Juan de Alicante.
C McKerlieThe Centre for Phenogenomics and Translation Medicine, The Hospital for Sick Children, Toronto, CANADA.
T MeehanEuropean Bioinformatics Institute (EBI), Hinxton, Cambridge, CB101ST, UK.
H von MelchnerDepartment of Molecular Haematology, University of Frankfurt Medical School, 60590 Frankfurt am Main, Germany.
M MooreIMPC, San Anselmo, California, US.
S A MurrayThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
A NagySamuel Lunenfeld Research Institute, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, Toronto, ON, M5G1X5, Canada.
Lmj NutterThe Centre for Phenogenomics and Translation Medicine, The Hospital for Sick Children, Toronto, CANADA.
G PavlovicCELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404 Illkirch-Graffenstaden, France.
A PomberoInstituto de Neurociencias (UMH-CSIC), San Juan de Alicante.
H ProsserThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
R Ramirez-SolisThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
M RingwaldThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
B RosenThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
N RosenthalThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
J RossantResearch Institute, The Hospital for Sick Children, SickKids Foundation, Toronto, ON, M5G2L3, Canada.
P Ruiz NoppingerDepartment of Vertebrate Genomics, Charité, 10115 Berlin, Germany.
E RyderThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
W C SkarnesThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
J SchickInstitute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
F SchnütgenDepartment of Molecular Haematology, University of Frankfurt Medical School, 60590 Frankfurt am Main, Germany.
P SchofieldDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB23EG, UK.
C SeisenbergerInstitute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.
M SelloumCELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), CNRS, INSERM, University of Strasbourg, 1 rue Laurent Fries, F-67404 Illkirch-Graffenstaden, France.
D SmedleyEuropean Bioinformatics Institute (EBI), Hinxton, Cambridge, CB101ST, UK.
E M SimpsonCentre for Molecular Medicine and Therapeutics at the BC Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
A F StewartBiotechnology Center (BIOTEC) of the Technische Universität Dresden, 01307 Dresden, Germany.
L TeboulMammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, OX110RD, UK.
G P Tocchini ValentiniIstituto di Biologia Cellulare, Consiglio Nazionale delle Ricerche (CNR), Monterotondo-Scalo, I-00015 Rome, Italy.
D ValenzuelaVelocigene Division, Regeneron Pharmaceuticals Inc., Tarrytown, New York, 10591, USA.
A WestThe Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101HH, UK.
W WurstInstitute of Developmental Genetics, Helmholtz Zentrum Muenchen, D-85764 Neuherberg, Germany.

Funding

Mouse Phenotyping Informatics Infrastructure - MP12UM1HG006370 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI Pilar Cacheiro Martinez, Helen Elizabeth Parkinson · 2016 to 2026
$20.4M
KOMP Phase II Mouse Production and CryopreservationU42OD011175 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LLOYD, KC KENT · 2012 to 2015
$18.9M
High Throughput Production and Cryopreservation of Knockout MiceU42OD011185 · OD · JACKSON LABORATORY · PI MURRAY, STEPHEN A, TAFT, ROBERT A · 2012 to 2015
$17.9M
Mouse Phenotyping Informatics Infrastruture - MP12U54HG006370 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI BROWN, STEVE, FLICEK, PAUL · 2011 to 2015
$11.4M
NHGRI NIH HHS U54 HG006370NHGRI NIH HHS UM1 HG006370NIH HHS U42 OD011175NIH HHS U42 OD011185
6 · The paper itself

Abstract

The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6,000 mutant mouse strains have been produced by the IKMC and mostly the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 inducible cre-driver mouse strains in a C57BL/6 background. Complementing the cre-driver resource, a collection of comprising 27 cre-driver rAAVs has also been produced. The resources can be easily accessed at the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds that enables the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research.

Identifiers

PMID39132094
PMCPMC11315453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.