ArticleBrain, behavior, & immunity - health2024
Multi-discrimination exposure and biological aging: Results from the midlife in the United States study.
Article in Brain, behavior, & immunity - health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed.
- Capturing wear in wear and tear: The negative-affect reactivity linked to discrimination is associated with biological age across two national samples of adults in the United States.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Unequal embodiment: racial and ethnic heterogeneity in the predictors and age-related health outcomes associated with accelerated biological aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Epigenetic entropy, socioeconomic differences, and health and lifespan in the Women's Health Initiative.Clinical epigenetics · 2026Article
- Neighborhood opportunity and cellular senescence in a national sample of U.S. adults.Social science & medicine (1982) · 2026Article
- Major Lifetime Discrimination Exposure Accelerates Brain Microstructural Aging: Diffusion MRI Evidence From MIDUS.Biopsychosocial science and medicine · 2026Article
- Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions.Frontiers in aging · 2026Review
- Psychosocial stressors, accelerated biological aging, and multiple morbidities: Evidence from an age-diverse sample.PloS one · 2026Article
- Gender differences in the association between marriage and epigenetic age.Frontiers in aging · 2026Article
- Aging rate indicators and the search for anti-aging drugs.Frontiers in science · 2026Article
- Relationship stress and epigenetic age acceleration among older U.S. adults in the Midlife in the United States study.Epigenomics · 2025Article
- Cumulative stress and epigenetic aging: Examining the role of psychological moderators.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- The role of stress proliferation in linking childhood stressors to accelerated biological aging.Social science & medicine (1982) · 2025Article
- Neighborhood Opportunity and Biological Aging: Results From the Midlife in the United States.Biopsychosocial science and medicine · 2025Article
- Racial/ethnic differences in the association of lifestyle factors with biological aging in NHANES, 1999-2018.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Examining the Health Risk Pathways Between Discrimination and Accelerated Biological Aging Among a Population-Based Sample of Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Tracking Epigenetic Biomarkers of Health and Aging During the Initial Year of Gender-Affirming Hormone Therapy.The Yale journal of biology and medicine · 2025Article
- Discrimination, Coping, and DNAm Accelerated Aging Among African American Mothers of the InterGEN Study.Epigenomes · 2025Article
- Major experiences of perceived discrimination across life and biological aging.Psychoneuroendocrinology · 2025Article
- Gerotherapeutics: aging mechanism-based pharmaceutical and behavioral interventions to reduce cancer racial and ethnic disparities.Journal of the National Cancer Institute · 2025Review
- Housing insecurity pathways to physiological and epigenetic manifestations of health among aging adults: a conceptual model.Frontiers in public health · 2025Review
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Discrimination is a social determinant of health and health disparities for which the biological mechanisms remain poorly understood. This study investigated the hypothesis that discrimination contributes to poor health outcomes by accelerating biological processes of aging. We analyzed survey and blood DNA methylation data from the Midlife in the United States (MIDUS) study (N = 1967). We used linear regression analysis to test associations of everyday, major, and workplace discrimination with biological aging measured by the DunedinPACE, PhenoAge, and GrimAge2 epigenetic clocks. MIDUS participants who reported more discrimination tended to exhibit a faster pace of aging and older biological age as compared to peers who reported less discrimination. Effect-sizes for associations tended to be larger for the DunedinPACE pace-of-aging clock (effect-size range r = 0.1-0.2) as compared with the PhenoAge and GrimAge2 biological-age clocks (effect-sizes r < 0.1) and for experiences of everyday and major discrimination as compared with workplace discrimination. Smoking status and body-mass index accounted for roughly half of observed association between discrimination and biological aging. Reports of discrimination were more strongly associated with accelerated biological aging among White as compared with Black participants, although Black participants reported more discrimination overall and tended to exhibit older biological age and faster biological aging. Findings support the hypothesis that experiences of interpersonal discrimination contribute to accelerated biological aging and suggest that structural and individual-level interventions to reduce discrimination and promote adaptive coping have potential to support healthy aging and build health equity.
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