Evidence map›Paper›PMID 39132076›Full record

ArticleGastro hep advances2022

Cirrhosis-Based Acute-on-Chronic Liver Failure Is Marked by Inflammation and Impaired Liver Regeneration Despite Stat3 Activation.

Christian M Lange, Kawther Al-Juboori, Josefine Rawitzer, Dorothe Moellmann, Martin Schlattjan, Sabrina Guckenbiehl, Katharina Willuweit, Ali Canbay, Hideo A Baba

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In one paragraph

Article in Gastro hep advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christian M LangeDepartment of Gastroenterology and Hepatology, University Hospital and University of Duisburg-Essen, Essen, Germany.
Kawther Al-JubooriDepartment of Gastroenterology and Hepatology, University Hospital and University of Duisburg-Essen, Essen, Germany.
Josefine RawitzerInstitute of Pathology, University Hospital and University of Duisburg-Essen, Essen, Germany.
Dorothe MoellmannInstitute of Pathology, University Hospital and University of Duisburg-Essen, Essen, Germany.
Martin SchlattjanInstitute of Pathology, University Hospital and University of Duisburg-Essen, Essen, Germany.
Sabrina GuckenbiehlDepartment of Gastroenterology and Hepatology, University Hospital and University of Duisburg-Essen, Essen, Germany.
Katharina WilluweitDepartment of Gastroenterology and Hepatology, University Hospital and University of Duisburg-Essen, Essen, Germany.
Ali CanbayDepartment of Internal Medicine, University Hospital Knappschaftskrankenhaus Bochum, Bochum, Germany.
Hideo A BabaInstitute of Pathology, University Hospital and University of Duisburg-Essen, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Acute-on-chronic liver failure (ACLF) is associated with excessive systemic inflammation, cell death, and organ failures. Yet, little is known about the hepatic histopathology of ACLF. Here, we assessed the histopathology and regenerative capacity of the liver in ACLF with or without cirrhosis. Methods: Liver specimens of patients with compensated cirrhosis (N = 37), acute decompensation (N = 40), and ACLF with (N = 18) or without (N = 10) cirrhosis were assessed for morphological features and the pro-regenerative Stat3 pathway. Results: ACLF was associated with high levels of lobular inflammation, tissue necrosis, and apoptosis. In patients with cirrhosis, the percentage of pStat3-positive hepatocytes was increasing with disease severity (3.5%/10.4%/21% for compensated cirrhosis/acute decompensation/cirrhosis-ACLF; Conclusion: Our study identifies hepatic inflammation and Stat3 activation as hallmarks of ACLF. In cirrhosis-ACLF, Stat3 activation does not appear to translate in effective liver regeneration, which is distinct from noncirrhotic ACLF.

Indexed as

Acute DecompensationCell DeathLiver CirrhosisSystemic Inflammation

Identifiers

PMID39132076
PMCPMC11308700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.