Evidence map›Paper›PMID 39131951›Full record

ArticleCurrent research in food science2024

Konjac supplementation can alleviate obesity induced by high-fat diet in mice by modulating gut microbiota and its metabolites.

Yuhang Wen, Baoting Chen, Jingrong Huang, Yadan Luo, Shuya Lv, Hao Qiu, Shuaibing Li, Songwei Liu, Lvqin He, Manli He and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in food science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. [Research Advancements in Gastric Capacity Intervention for Childhood and Adolescent Obesity].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuhang WenLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Baoting ChenLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Jingrong HuangLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Yadan LuoLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Shuya LvLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Hao QiuLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Shuaibing LiLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Songwei LiuLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Lvqin HeLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Manli HeLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Zehui YuLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Mingde ZhaoLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Qian YangLaboratory Animal Centre, Southwest Medical University, Luzhou, China.
Dong LiCollege of Bioengineering, Sichuan University of Science and Engineering, Yibin, 643002, China.
Congwei GuLaboratory Animal Centre, Southwest Medical University, Luzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a multi-factorial disease, obesity has become one of the major health problems in the world, and it is still increasing rapidly. Konjac supplementation, as a convenient dietary therapy, has been shown to be able to regulate gut microbiota and improve obesity. However, the specific mechanism by which konjac improves obesity through gut microbiota remains to be studied. In this study, a high-fat diet (HFD) was used to induce a mouse obesity model, and 16S rDNA sequencing and an untargeted metabolomics were used to investigate the impact of konjac on gut microbiota and gut metabolites in HFD-induced obese mice. The results show that konjac can reduce the body weight, adipose tissue weight, and lipid level of high-fat diet induced obese mice by changing the gut microbiota structure and gut metabolic profile. Association analysis revealed that konjac supplementation induced changes in gut microbiota, resulting in the up-regulation of 7-dehydrocholesterol and trehalose 6-phosphate, as well as the down-regulation of glycocholic acid and ursocholic acid within the Secondary bile acid biosynthesis pathway, ultimately leading to improvements in obesity. Among them,

Indexed as

16S rDNA sequencingAssociation analysisHigh-fat dietKonjac supplementationObesityUntargeted metabolomics

Identifiers

PMID39131951
PMCPMC11315163

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.