Evidence map›Paper›PMID 39131928›Full record

ArticleJournal of the Society for Cardiovascular Angiography & Interventions

Intravascular Lithotripsy for Peripheral Artery Calcification: Mid-term Outcomes From the Randomized Disrupt PAD III Trial.

Gunnar Tepe, Marianne Brodmann, William Bachinsky, Andrew Holden, Thomas Zeller, Sarang Mangalmurti, Claus Nolte-Ernsting, Renu Virmani, Sahil A Parikh, William A Gray

Abstract read
In one paragraph

Article in Journal of the Society for Cardiovascular Angiography & Interventions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Device design and applications of the novel JAVELIN peripheral intravascular lithotripsy catheter.Journal of vascular surgery cases and innovative techniques · 2026
    Article
  7. Article
  8. Intravascular lithotripsy of the femoropopliteal arteries: analysis of a prospective two-center pilot study.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Shocking safely: Intravascular lithotripsy to under expanded interwoven stent.Journal of vascular surgery cases and innovative techniques · 2025
    Article
  14. Review
  15. [AVK III: Below the knee].Innere Medizin (Heidelberg, Germany) · 2025
    Review
  16. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gunnar TepeDepartment of Diagnostic and Interventional Radiology, RoMed Klinikum, Rosenheim, Germany.
Marianne BrodmannDivision of Angiology, Medical University Graz, Graz, Austria.
William BachinskyUPMC Heart and Vascular Institute, UPMC-Pinnacle Health, Harrisburg, Pennsylvania.
Andrew HoldenDepartment of Interventional Radiology, Auckland City Hospital, Auckland, New Zealand.
Thomas ZellerDivision of Angiology, Department of Internal Medicine, Universitäts-Herzzentrum Freiburg & Bad Krozingen, Bad Krozingen, Germany.
Sarang MangalmurtiDepartment of Interventional Cardiology, Main Line Hospitals, Bryn Mawr, Pennsylvania.
Claus Nolte-ErnstingDepartment of Radiology, Evangelisches Krankenhaus Mülheim an der Ruhr, Mülheim an der Ruhr, Germany.
Renu VirmaniCVPath Institute, Inc, Gaithersburg, Maryland.
Sahil A ParikhCenter for Interventional Vascular Therapy, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York.
William A GrayDivision of Cardiology, Main Line Health, Wynnewood, Pennsylvania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endovascular treatment of calcified peripheral artery lesions may be associated with suboptimal vessel expansion, increased complication risk, and reduced long-term patency. The primary endpoint from the Disrupt PAD III randomized controlled trial (RCT) demonstrated superior procedural success in patients treated with intravascular lithotripsy (IVL) vs percutaneous transluminal angioplasty (PTA). The present study evaluates primary patency after 1 and 2 years in this randomized population. Methods: The Disrupt PAD III RCT enrolled 306 patients with moderately-to-severely calcified femoropopliteal arteries treated with IVL ( Results: Primary patency at 1 year was significantly greater in the IVL arm (80.5% vs 68.0%, Conclusions: The Disrupt PAD III RCT secondary endpoint of superior 1-year primary patency was achieved, confirming the consistent safety and effectiveness of IVL followed by DCB treatment to facilitate a durable approach for patients with heavily calcified femoropopliteal arteries largely without stent requirement.

Indexed as

Calcificationdrug-coated balloonfemoropopliteal arteryintravascular lithotripsyperipheral artery disease

Identifiers

PMID39131928
PMCPMC11307657

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.