Evidence map›Paper›PMID 39131911›Full record

ArticlePNAS nexus2024

CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca

Aya Ikeda, Hongrui Meng, Daisuke Taniguchi, Muneyo Mio, Manabu Funayama, Kenya Nishioka, Mari Yoshida, Yuanzhe Li, Hiroyo Yoshino, Tsuyoshi Inoshita and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Aya IkedaDepartment of Neurology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
Hongrui MengResearch Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID https://orcid.org/0009-0000-8023-7603
Daisuke TaniguchiDepartment of Neurology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID https://orcid.org/0000-0002-8729-7016
Muneyo MioDepartment of Neurology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID https://orcid.org/0009-0009-1110-3455
Manabu FunayamaDepartment of Neurology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID https://orcid.org/0000-0002-7412-3631
Kenya NishiokaDepartment of Neurology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
Mari YoshidaDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.ORCID https://orcid.org/0000-0002-8520-6184
Yuanzhe LiDepartment of Neurology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
Hiroyo YoshinoResearch Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID https://orcid.org/0009-0002-6641-8728
Tsuyoshi InoshitaDepartment of Neurology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
Kahori Shiba-FukushimaDepartment of Drug Development for Parkinson's Disease, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.
Yohei OkuboDepartment of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID https://orcid.org/0000-0001-7611-3237
Takashi SakuraiDepartment of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID https://orcid.org/0000-0001-9515-6574
Taku AmoDepartment of Applied Chemistry, National Defense Academy, Yokosuka, Kanagawa 239-8686, Japan.
Ikuko AibaDepartment of Neurology, NHO Higashinagoya National Hospital, Meito-ku, Nagoya, Aichi 465-8620, Japan.
Yufuko SaitoDepartment of Neurology, NHO Higashinagoya National Hospital, Meito-ku, Nagoya, Aichi 465-8620, Japan.
Yuko SaitoBrain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo 173-0015, Japan.
Shigeo MurayamaBrain Bank for Aging Research (Department of Neuropathology), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo 173-0015, Japan.ORCID https://orcid.org/0000-0001-9709-5242
Naoki AtsutaDepartment of Neurology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan.ORCID https://orcid.org/0000-0002-4911-2690
Ryoichi NakamuraDepartment of Neurology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan.ORCID https://orcid.org/0000-0002-4854-3579
Genki TohnaiDivision of ALS Research, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan.
Yuishin IzumiDepartment of Neurology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8503, Japan.ORCID https://orcid.org/0000-0002-3048-9041
Mitsuya MoritaDivision of Neurology, Department of Internal Medicine, Jichi Medical University, Shimotsuke, Tochigi 329-0498, Japan.
Asako TamuraDepartment of Neurology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Osamu KanoDepartment of Neurology, Toho University Faculty of Medicine, Ota-ku, Tokyo 143-8541, Japan.
Masaya OdaDepartment of Neurology, Vihara Hananosato Hospital, Miyoshi, Hiroshima 728-0001, Japan.
Satoshi KuwabaraDepartment of Neurology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba 260-8670, Japan.ORCID https://orcid.org/0000-0002-4716-8578
Toru YamashitaDepartment of Neurology, Okayama University Graduate School of Medicine, Kita-ku, Okayama 700-8558, Japan.ORCID https://orcid.org/0000-0003-3634-5679
Jun SoneDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.ORCID https://orcid.org/0000-0002-9057-7609
Ryuji KajiDepartment of Clinical Neuroscience, Tokushima University, Tokushima 770-8503, Japan.
Gen SobueAichi Medical University, Nagakute, Aichi 480-1195, Japan.
Yuzuru ImaiDepartment of Neurology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.ORCID https://orcid.org/0000-0003-2924-5231
Nobutaka HattoriDepartment of Neurology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CHCHD2 and CHCHD10, linked to Parkinson's disease and amyotrophic lateral sclerosis-frontotemporal dementia (ALS), respectively, are mitochondrial intermembrane proteins that form a heterodimer. This study aimed to investigate the impact of the CHCHD2 P14L variant, implicated in ALS, on mitochondrial function and its subsequent effects on cellular homeostasis. The missense variant of CHCHD2, P14L, found in a cohort of patients with ALS, mislocalized CHCHD2 to the cytoplasm, leaving CHCHD10 in the mitochondria.

Indexed as

amyotrophic lateral sclerosisCa2+ dynamicsmitochondriaParkinson's diseaseTDP-43

Identifiers

PMID39131911
PMCPMC11316225

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.