Evidence map›Paper›PMID 39131888›Full record

ArticleSensors and actuators. B, Chemical2024

An Acoustofluidic Picoinjector.

Ty Naquin, Shivam Jain, Jinxin Zhang, Xianchen Xu, Gary Yao, Chloe M Naquin, Shujie Yang, Jianping Xia, Janna Wang, Sebastian Jimenez and 1 more

Abstract read
In one paragraph

Article in Sensors and actuators. B, Chemical, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. An Ultrasensitive Fluorescent Immunoassay Based on R-CDs@SiOApplied biochemistry and biotechnology · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ty NaquinThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Shivam JainThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Jinxin ZhangThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Xianchen XuThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Gary YaoThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Chloe M NaquinThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Shujie YangThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Jianping XiaThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Janna WangThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Sebastian JimenezThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.
Tony Jun HuangThomas Lord Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27708, USA.

Funding

Automated High-purity Exosome isolation-based AD diagnostics system (AHEADx)R01AG084098 · NIA · DUKE UNIVERSITY · PI Tony Jun Huang · 2023 to 2026
$3.1M
Acoustofluidic Separation of Placental Nanovesicle Subpopulations in Obstetrical DiseasesR01HD103727 · NICHD · STANFORD UNIVERSITY · PI HUANG, TONY JUN, SADOVSKY, YOEL · 2021 to 2025
$2.6M
Development of a digital acoustofluidic system for automating liquid handling in biomedical researchR01GM141055 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2021 to 2024
$1.9M
Harmonic Acoustics for Neighboring cell Dynamic studies(HANDs)R01GM145960 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE, LUKE P. · 2022 to 2025
$1.8M
Development of a multifunctional, acoustofluidic 3D bioprinter with single-cell resolutionR01GM144417 · NIGMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Zhenhua Tian · 2022 to 2026
$1.8M
Development of an acoustofluidic device for high-throughput 3D imaging and sorting of C. elegansR44OD024963 · OD · ASCENT BIO-NANO TECHNOLOGIES, INC. · PI WANG, LIN · 2022 to 2023
$1.7M
Three-Dimensional (3D) Acoustofluidic Scanning Nanoscope with Super Resolution and Large Field of ViewR01GM143439 · NIGMS · UNIVERSITY OF DAYTON · PI AGHA, IMAD, HUANG, TONY JUN · 2021 to 2024
$1.5M
NIA NIH HHS R01 AG084098NICHD NIH HHS R01 HD103727NIGMS NIH HHS R01 GM141055NIGMS NIH HHS R01 GM143439NIGMS NIH HHS R01 GM144417NIGMS NIH HHS R01 GM145960NIH HHS R44 OD024963
6 · The paper itself

Abstract

Droplet microfluidics has emerged as a valuable technology for a multitude of chemical and biomedical applications, offering the capability to create independent microenvironments for high-throughput assays. Central to numerous droplet microfluidic applications is the picoinjection of materials into individual droplets, yet existing picoinjection methods often exhibit high power requirements, lack biocompatibility, and/or suffer from limited controllability. Here, we present an acoustofluidic picoinjector that generates acoustic pressure at the droplet interface to enable on-demand, energy-efficient, and biocompatible injection at high precision. We validate our platform by performing acid-base titrations by iteratively injecting picoliter volume reagents into droplets to induce pH transitions detectable by color change in solution. Additionally, we demonstrate the versatility of the acoustofluidic picoinjector in the synthesis of metallic nanoparticles, yielding highly monodisperse and reproducible particle morphologies compared to conventional bulk-phase techniques. By facilitating controlled delivery of reagents or biological samples with unparalleled accuracy, acoustofluidic picoinjection broadens the utility of droplet microfluidics for a myriad of applications in chemical and biological research.

Indexed as

Acoustofluidicsdroplet microfluidicsnanoparticle synthesispicoinjection

Identifiers

PMID39131888
PMCPMC11308560

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.