Evidence map›Paper›PMID 39131792›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2024

Treatment Responses in Histologic Versus Molecular Diagnoses of Lung Rejection.

A Zajacova, M Mackova, K Halloran, P Gauthier, J Balko, M Guney, D Rakita, M Svorcova, J Kolarik, J Vachtenheim and 6 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Exploring acute cellular rejection in lung transplantation: insights from donor-derived cell-free DNA analysis.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia · 2026
    Article
  2. Post-lung transplant surveillance in 2026: current practice, variability, and the need for standardization.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Review
  3. Innovations in Lung Transplant Research and Practice: The Future is Now.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

A ZajacovaPrague Lung Transplant Program, Department of Pneumology, Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czechia.
M MackovaAlberta Transplant Applied Genomics Centre, Edmonton, AB, Canada.
K HalloranDepartment of Medicine, University of Alberta, Edmonton, AB, Canada.
P GauthierAlberta Transplant Applied Genomics Centre, Edmonton, AB, Canada.
J BalkoDepartment of Pathology and Molecular Medicine, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia.
M GuneySecond Faculty of Medicine, Charles University, Prague, Czechia.
D RakitaPrague Lung Transplant Program, Department of Pneumology, Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czechia.
M SvorcovaPrague Lung Transplant Program, 3rd Department of Surgery, First Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czechia.
J KolarikPrague Lung Transplant Program, 3rd Department of Surgery, First Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czechia.
J VachtenheimPrague Lung Transplant Program, 3rd Department of Surgery, First Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czechia.
J PozniakPrague Lung Transplant Program, 3rd Department of Surgery, First Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czechia.
J SimonekPrague Lung Transplant Program, 3rd Department of Surgery, First Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czechia.
L FilaPrague Lung Transplant Program, Department of Pneumology, Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czechia.
R LischkePrague Lung Transplant Program, 3rd Department of Surgery, First Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czechia.
P F HalloranAlberta Transplant Applied Genomics Centre, Edmonton, AB, Canada.
J HavlinPrague Lung Transplant Program, 3rd Department of Surgery, First Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Histologic evaluation of allograft biopsies after lung transplantation has several limitations, suggesting that molecular assessment using tissue transcriptomics could improve biopsy interpretation. This single-center, retrospective cohort study evaluated discrepancies between the histology of transbronchial biopsies (TBBs) with no rejection (NR) and T-cell mediated rejection (TCMR) by molecular diagnosis. The accuracy of diagnosis was assessed based on response to treatment. 54 TBBs from Prague Lung Transplant Program obtained between December 2015 and January 2020 were included. Patients with acute cellular rejection (ACR) grade ≥ 1 by histology received anti-rejection treatment. Response to therapy was defined as an increase in FEV1 of ≥ 10% 4 weeks post-biopsy compared to the pre-biopsy value. Among the 54 analyzed TBBs, 25 (46%) were concordant with histology, while 29 (54%) showed discrepancies. ACR grade 0 was found in 12 TBBs (22%) and grade A1 ≥ 1 in 42 TBBs (78%). Treatment response was present in 14% in the NR group and in 50% in the TCMR group (

Indexed as

Graft RejectionLung TransplantationAdultAgedBiopsyFemaleHumansImmunosuppressive AgentsLungMaleMiddle AgedRetrospective StudiesTreatment OutcomeImmunosuppressive Agentsacute cellular rejectiongene expressionhistopathologylung transplantationmolecular biology

Identifiers

PMID39131792
PMCPMC11310027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.