Evidence map›Paper›PMID 39131661›Full record

ArticleJournal of the Society for Cardiovascular Angiography & Interventions

Longer-Term Outcomes Following Mechanical Thrombectomy for Intermediate- and High-Risk Pulmonary Embolism: 6-Month FLASH Registry Results.

Sameer Khandhar, Wissam Jaber, Matthew C Bunte, Kenneth Cho, Mitchell D Weinberg, Bushra Mina, Brian Stegman, Jeffrey Pollak, Akhil Khosla, Fakhir Elmasri and 6 more

Registry-linked trialAbstract read
In one paragraph

Article in Journal of the Society for Cardiovascular Angiography & Interventions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03761173 (FlowTriever All-Comer Registry for Patient Safety and Hemodynamics), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03761173 completednot on this map

FlowTriever All-Comer Registry for Patient Safety and Hemodynamics (FLASH)

Typeobservational_patient_registrySponsorInari MedicalRan2018 to 2024Enrolled1,200ConditionsPE - Pulmonary Embolism, PE - Pulmonary ThromboembolismArmsFlowTriever System, Anticoagulation Agents
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
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  5. Review
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  14. Extraction of Chronic Pulmonary Embolism With Aspiration Thrombectomy: A Case Report.Journal of the Society for Cardiovascular Angiography & Interventions
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sameer KhandharDivision of Cardiovascular Medicine, Penn Presbyterian Medical Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Wissam JaberEmory University Hospital, Atlanta, Georgia.
Matthew C BunteSaint Luke's Mid America Heart Institute, Kansas City, Missouri.
Kenneth ChoSaint Luke's Mid America Heart Institute, Kansas City, Missouri.
Mitchell D WeinbergDepartment of Cardiology, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, Staten Island University Hospital, Staten Island, New York.
Bushra MinaDepartment of Pulmonary Critical Care Medicine, Lenox Hill Hospital, Northwell Health, Zucker School of Medicine at Hofstra/Northwell, New York, New York.
Brian StegmanCentraCare Heart and Vascular Center, St Cloud, Minnesota.
Jeffrey PollakDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Akhil KhoslaDepartment of Pulmonary, Critical Care and Sleep Medicine, Yale University, Yale New Haven Hospital, New Haven, Connecticut.
Fakhir ElmasriDivision of Interventional Radiology, Lakeland Regional Medical Center, Lakeland, Florida.
David ZlotnickDivision of Cardiovascular Medicine, University at Buffalo, Gates Vascular Institute, Buffalo General Medical Center, Buffalo, New York.
Daniel BrancheauAscension Genesys Hospital, Grand Blanc, Michigan.
Gerald KoenigDivision of Cardiovascular Medicine, Henry Ford Health System, Wayne State University School of Medicine, Detroit, Michigan.
Mohannad BisharatMemorial Hospital Jacksonville, Jacksonville, Florida.
Jun LiHarrington Heart and Vascular Institute, University Hospitals, Cleveland, Ohio.
Catalin TomaHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mechanical thrombectomy provides rapid hemodynamic improvements after acute pulmonary embolism (PE), but long-term benefits are uncertain. Methods: FlowTriever All-comer Registry for Patient Safety and Hemodynamics is a prospective, single-arm, multicenter registry of patients with acute PE treated with the FlowTriever System (Inari Medical). Six-month outcomes including modified Medical Research Council dyspnea scores (MMRCD), right ventricular (RV) function, 6-minute walk test distances, and PE quality-of-life scores (QoL) were assessed. Results: In total, 799 patients were enrolled and 75% completed the study with a mean follow-up of 204 ± 46 days. Demographic characteristics included 54.1% men, mean age of 61.2 years, 77.1% intermediate-high-risk PE, and 8.0% high-risk PE. All-cause mortality was 4.6% at study completion. The proportion of patients with normal echocardiographic RV function increased from 15.1% at baseline to 95.1% at 6 months ( Conclusions: In this large diverse group of PE patients, 6-month all-cause mortality, chronic thromboembolic pulmonary hypertension, and chronic thromboembolic disease were low following thrombectomy with the FlowTriever system. Significant improvements in RV function, patient symptoms, exercise capacity, and QoL were observed at 6 months, suggesting that rapid extraction of thrombus may prevent long-term sequelae in patients with PE.

Indexed as

long-term outcomesmechanical thrombectomypercutaneous interventionpulmonary embolism

Identifiers

PMID39131661
PMCPMC11307656

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.