ArticleJournal of the Society for Cardiovascular Angiography & Interventions
Ejection Fraction Improvement Following Contemporary High-Risk Percutaneous Coronary Intervention: RESTORE EF Study Results.
Article in Journal of the Society for Cardiovascular Angiography & Interventions. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04648306 (Restore EF Observational Study), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Restore EF Observational Study (in High-risk PCI)
Who cites it
20 citing papers in PubMed.
- Characteristics and Outcomes of Older Patients Undergoing Protected Percutaneous Coronary Intervention With Impella.Journal of the American Heart Association · 2025Trial
- Axial Flow Percutaneous Ventricular Assist Devices: Physiology, Procedural Considerations, and Clinical Applications-A State-of-the-Art Review.Structural heart : the journal of the Heart Team · 2026Review
- Contemporary evidence in protected percutaneous coronary intervention: a case-based review.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Patient selection for complex, high-risk indicated percutaneous coronary intervention procedures: an overview.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Optimizing revascularization in the high-risk heart: Impella™-facilitated percutaneous coronary intervention in multivessel coronary artery disease with reduced left ventricular ejection fraction and mitral regurgitation.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Ischaemic cardiomyopathy with a significant improvement in left ventricular wall motion following revascularization for a honeycomb-like structure of the left anterior descending artery: a case report.European heart journal. Case reports · 2026Article
- Impella vs. IABP in Non-emergent High-Risk PCI: Outcomes and LVEF Recovery from a Large US EHR Study.Cardiology and therapy · 2026Article
- Mechanical Circulatory Support With Impella in High-Risk Patients With Chronic Total Occlusion and Complex Multivessel Disease.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2025Article
- Pulsatile Left Ventricular Assistance in High-Risk Percutaneous Coronary Interventions: Short-Term Outcomes.Journal of clinical medicine · 2024Article
- Role of Mechanical Circulatory Support in Complex High-Risk and Indicated Percutaneous Coronary Intervention: Current Indications, Device Options, and Potential Complications.Journal of clinical medicine · 2024Review
- Mechanical Circulatory Support with Impella: Principles, Evidence, and Daily Practice.Journal of clinical medicine · 2024Review
- Complete percutaneous coronary revascularization: An elegant solution to left ventricular dysfunction caused by severe coronary artery disease.Clinical case reports · 2024Article
- The use of mechanical circulatory support in elective high-risk percutaneous coronary interventions: a literature-based review.European heart journal open · 2024Review
- Clinical characteristics and outcomes of patients requiring prolonged mechanical circulatory support after high-risk percutaneous coronary intervention.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024Article
- Predictors of left ventricular ejection fraction in high-risk percutaneous coronary interventions.Frontiers in cardiovascular medicine · 2024Article
- Mechanical Support Strategies for High-Risk Procedures in the Invasive Cardiac Catheterization Laboratory: A State-of-the-Art Review.Journal of clinical medicine · 2023Review
- Predicting left ventricular functional recovery in ischaemic cardiomyopathy: needs and challenges.European heart journal supplements : journal of the European Society of Cardiology · 2023Article
- Impella-Supported Optical Coherence Tomography-Guided Aggressive Rotational Atherectomy for Heavily Calcified Lesions in Left Main Trunk Bifurcation in a Patient with Severe Left Ventricular Systolic Dysfunction.Case reports in cardiology · 2023Article
- Does Mechanical Circulatory Support-Assisted Percutaneous Coronary Intervention Improve Left Ventricular Function?Journal of the Society for Cardiovascular Angiography & InterventionsArticle
- Current Landscape and Future Directions of Coronary Revascularization in Ischemic Systolic Heart Failure: A Review.Journal of the Society for Cardiovascular Angiography & InterventionsReview
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite many reports of clinical outcomes in patients undergoing high-risk percutaneous coronary intervention (HRPCI) with hemodynamic support, little is known about whether this approach improves left ventricular ejection fraction (LVEF). The purpose of the present observational study was to examine, in an ideal patient population with Impella-supported HRPCI, whether there is an impact on left ventricular function at midterm follow-up. Methods: RESTORE EF is a multicenter, retrospective analysis of a prospectively collected observational data set that aimed to assess 90-day LVEF in patients undergoing Impella-supported nonemergent HRPCI (NCT04648306), who survived with no intervening cardiac procedures prior to the primary endpoint follow-up window (90-day LVEF assessment). Secondary endpoints included change in New York Heart Association Functional Classification and Canadian Cardiovascular Society Angina Grade at the last follow-up. Results: From August 2019 to May 2021, 406 patients were enrolled at 22 US sites. Age was 70.2 ± 11.4 years; 26% were female. In paired assessment at 90-day follow-up, baseline LVEF improved from 35 ± 15% to 45 ± 14% ( Conclusions: In an ideal cohort of HRPCI patients, there is a signal that hemodynamically supported HRPCI affords significant improvement in 90-day LVEF, with complete revascularization associated with greater LVEF improvement. These hypothesis-generating findings merit further assessment in large, all-comer studies and randomized trials.
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