Evidence map›Paper›PMID 39131393›Full record

ArticlebioRxiv : the preprint server for biology2024

Loss of

Grace Z Yu, Nicole A J Krentz, Liz Bentley, Meng Zhao, Keanu Paphiti, Han Sun, Julius Honecker, Marcus Nygård, Hesam Dashti, Ying Bai and 16 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Grace Z YuOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Nicole A J KrentzWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID 0000-0003-3622-2652
Liz BentleyMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK.
Meng ZhaoDepartment of Pathology, Stanford University, Stanford, CA, United States.
Keanu PaphitiOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Han SunDivision of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Julius HoneckerElse Kröner-Fresenius-Center for Nutritional Medicine, Chair of Nutritional Medicine, School of Life Science, Technical University of Munich, 85354 Freising, Germany.
Marcus NygårdFunctional Genomics & Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Hesam DashtiBroad Institute of MIT and Harvard, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.
Ying BaiMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK.
Madeleine ReidMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK.
Swaraj ThamanDivision of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Martin WabitschDivision of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany.
Varsha RajeshDivision of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Jing YangDivision of Endocrinology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Katia K MattisOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Fernando AbaituaWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Ramon CaseroMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK.
Hans HaunerElse Kröner-Fresenius-Center for Nutritional Medicine, Chair of Nutritional Medicine, School of Life Science, Technical University of Munich, 85354 Freising, Germany.
Joshua W KnowlesStanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
Joy Y WuDivision of Endocrinology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Susanne MandrupFunctional Genomics & Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Melina ClaussnitzerBroad Institute of MIT and Harvard, Novo Nordisk Foundation Center for Genomic Mechanisms of Disease & Type 2 Diabetes Systems Genomics Initiative, Cambridge, MA, USA.
Katrin J SvenssonDepartment of Pathology, Stanford University, Stanford, CA, United States.
Roger D CoxMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK.
Anna L GloynOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-1205-1844

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Bridging the gap between type 2 diabetes GWAS and therapeutic targetsUM1DK126185 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CLAUSSNITZER, MELINA C, GLOYN, ANNA LOUISE · 2020 to 2024
$9.5M
Mechanisms controlling fructose uptake and utilizationR01DK125260 · NIDDK · STANFORD UNIVERSITY · PI Katrin Jennifer Svensson · 2020 to 2026
$3.5M
Characterization of novel insulin resistance genes by gene editing, high-throughput phenotyping and in vivo studiesR01DK120565 · NIDDK · STANFORD UNIVERSITY · PI KNOWLES, JOSHUA WILEY · 2019 to 2023
$3.2M
Mechanisms of NAT2 Regulation of Insulin Resistance and Mitochondrial DysfunctionR01DK116750 · NIDDK · STANFORD UNIVERSITY · PI KNOWLES, JOSHUA WILEY · 2019 to 2023
$2.4M
Beyond GWAS of insulin resistance: An integrated approach to translate genetic association to functionR01DK106236 · NIDDK · STANFORD UNIVERSITY · PI KNOWLES, JOSHUA WILEY · 2016 to 2020
$2.4M
Investigating Isthmin as an adipose-to-muscle messenger that promotes muscle protein synthesisK99AR081618 · NIAMS · STANFORD UNIVERSITY · PI ZHAO, MENG · 2023 to 2024
$182k
NIAMS NIH HHS K99 AR081618NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK106236NIDDK NIH HHS R01 DK116750NIDDK NIH HHS R01 DK120565NIDDK NIH HHS R01 DK125260NIDDK NIH HHS UM1 DK126185Wellcome Trust 200837/Z/16/Z
6 · The paper itself

Abstract

There are multiple independent genetic signals at the

Indexed as

adipocyteDiabetesinsulin sensitivityRREB1transcription factor

Identifiers

PMID39131393
PMCPMC11312556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.