Evidence map›Paper›PMID 39131366›Full record

ArticlebioRxiv : the preprint server for biology2024

Mechanism of neurodegeneration mediated by clonal inflammatory microglia.

Rocio Vicario, Stamatina Fragkogianni, Maria Pokrovskii, Carina Mayer, Estibaliz Lopez-Rodrigo, Yang Hu, Masato Ogishi, Araitz Alberdi, Ann Baako, Oyku Ay and 27 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Rocio VicarioImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Stamatina FragkogianniImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Maria PokrovskiiImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Carina MayerImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Estibaliz Lopez-RodrigoImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Yang HuDepartment of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell New York, NY 10021, USA.
Masato OgishiSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, 10065 NY, USA.ORCID 0000-0003-2421-7389
Araitz AlberdiImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Ann BaakoImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Oyku AyImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Isabelle PluDepartment of Neuropathology, Pitié-Salpêtrière Hospital, APHP-Sorbonne Université, Paris, France.ORCID 0000-0002-1956-0150
Véronique SazdovitchDepartment of Neuropathology, Pitié-Salpêtrière Hospital, APHP-Sorbonne Université, Paris, France.
Sebastien HeritierFrench Langerhans cell histiocytosis registry, Department of Pediatric Hematology and Oncology, Trousseau Hospital, AP-HP, Paris, France.
Fleur Cohen-AubartDepartment of Internal Medicine & Institut E3M, Pitié-Salpêtrière Hospital, APHP-Sorbonne Université, Paris, France.
Natalia ShorDepartment of Neuroradiology, Pitié-Salpêtrière Hospital, APHP-Sorbonne Université, Paris, France.
Makoto MiyaraCenter for Immunology and Infectious Diseases (CIMI-PARIS), Pitié-Salpêtrière Hospital, APHP-Sorbonne Université, Paris, France.
Florence Nguyen-KhacDepartment of Hematology, Pitié-Salpêtrière Hospital, APHP-Sorbonne Université, Paris, France.
Agnes VialeMarie-Josée & Henry R. Kravis Center for Molecular Oncology, MSKCC, New York, New York 10065, USA.
Ahmed IdbaihSorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neurologie 2-Mazarin, F-75013, Paris, France.
Zahir AmouraDepartment of Neuroradiology, Pitié-Salpêtrière Hospital, APHP-Sorbonne Université, Paris, France.
Marc K RosenblumDepartment of Pathology, MSKCC, New York, New York 10065, USA.
Haochen ZhangHuman Oncology and Pathogenesis Program, MSKCC, New York, NY, USA).
Elias-Ramzey KarnoubHuman Oncology and Pathogenesis Program, MSKCC, New York, NY, USA).
Palash SashittalDepartment of Computer Science, Princeton University.
Akhil JakatdarDepartment of Computer Science, Princeton University.
Christine A Iacobuzio-DonahueDepartment of Pathology, MSKCC, New York, New York 10065, USA.ORCID 0000-0002-4672-3023
Omar Abdel-WahabHuman Oncology and Pathogenesis Program, MSKCC, New York, NY, USA).
Viviane TabarDepartment of Neurosurgery, and Center for Stem Cell Biology, MSKCC, New York, NY, USA.
Nicholas D SocciMarie-Josée & Henry R. Kravis Center for Molecular Oncology, MSKCC, New York, New York 10065, USA.
Olivier ElementoDepartment of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell New York, NY 10021, USA.
Eli L DiamondDepartment of Neurosurgery, and Center for Stem Cell Biology, MSKCC, New York, NY, USA.
Bertrand BoissonSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, 10065 NY, USA.
Jean-Laurent CasanovaSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, 10065 NY, USA.
Danielle SeilheanDepartment of Neuropathology, Pitié-Salpêtrière Hospital, APHP-Sorbonne Université, Paris, France.
Julien HarocheDepartment of Internal Medicine & Institut E3M, Pitié-Salpêtrière Hospital, APHP-Sorbonne Université, Paris, France.
Jean DonadieuFrench Langerhans cell histiocytosis registry, Department of Pediatric Hematology and Oncology, Trousseau Hospital, AP-HP, Paris, France.ORCID 0000-0002-4485-146X
Frederic GeissmannImmunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Macrophage development and specification in mice.R01AI130345 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Frederic Geissmann · 2017 to 2026
$5.7M
Role of Microglia Somatic Variants in Neurodegenerative DiseasesR01NS115715 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI GEISSMANN, FREDERIC · 2019 to 2023
$5.0M
Lineages and pathophysiology of clonal histiocytic disordersR01HL138090 · NHLBI · SLOAN-KETTERING INST CAN RESEARCH · PI GEISSMANN, FREDERIC · 2017 to 2020
$2.9M
NCI NIH HHS P30 CA008748NHLBI NIH HHS R01 HL138090NIAID NIH HHS R01 AI130345NINDS NIH HHS R01 NS115715
6 · The paper itself

Abstract

Langerhans cell Histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal myeloid disorders, associated with MAP-Kinase activating mutations and an increased risk of neurodegeneration. Surprisingly, we found pervasive PU.1

Identifiers

PMID39131366
PMCPMC11312538

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.