Evidence map›Paper›PMID 39131354›Full record

ArticlebioRxiv : the preprint server for biology2024

Dietary fiber content in clinical ketogenic diets modifies the gut microbiome and seizure resistance in mice.

Ezgi Özcan, Kristie B Yu, Lyna Dinh, Gregory R Lum, Katie Lau, Jessie Hsu, Mariana Arino, Jorge Paramo, Arlene Lopez-Romero, Elaine Y Hsiao

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ezgi ÖzcanDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Kristie B YuDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Lyna DinhDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Gregory R LumDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Katie LauDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Jessie HsuDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Mariana ArinoDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095.
Jorge ParamoUCLA Goodman-Luskin Microbiome Center, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Arlene Lopez-RomeroUCLA Goodman-Luskin Microbiome Center, Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Elaine Y HsiaoDepartment of Integrative Biology & Physiology, University of California, Los Angeles, Los Angeles, CA 90095.

Funding

Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic DietR01NS115537 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAO, ELAINE · 2020 to 2024
$1.7M
NINDS NIH HHS R01 NS115537
6 · The paper itself

Abstract

The gut microbiome is emerging as an important modulator of the anti-seizure effects of the classic ketogenic diet. However, many variations of the ketogenic diet are used clinically to treat refractory epilepsy, and how different dietary formulations differentially modify the gut microbiome in ways that impact seizure outcome is poorly understood. We find that clinically prescribed ketogenic infant formulas vary in macronutrient ratio, fat source, and fiber content and also in their ability to promote resistance to 6-Hz psychomotor seizures in mice. By screening specific dietary variables for their effects on a model human infant microbial community, we observe that dietary fiber, rather than fat ratio or source, drives substantial metagenomic shifts. Addition of dietary fiber to a fiber-deficient ketogenic formula restores seizure resistance, and supplementing protective ketogenic formulas with excess dietary fiber further potentiates seizure resistance. By screening 13 fiber sources and types, we identify distinct subsets of metagenomic responses in the model human infant microbial community that correspond with increased seizure resistance in mice. In particular, supplementation with seizure-protective fibers enriches microbial representation of genes related to queuosine biosynthesis and preQ

Identifiers

PMID39131354
PMCPMC11312565

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.