In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
17 authors.
Natalia KrawczynskaDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0000-0002-1882-6009 Yu WangDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0000-0001-7815-2600 Ki LimDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0009-0008-4981-946X Anasuya Das GuptaDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0000-0002-1273-0620 Adam LenczowskiDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.
Marwan AbughazalehDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0009-0003-9954-5210 Shruti V BendreDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0000-0002-6391-8930 Lara I KockayaDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0000-0001-9824-2857 Claire P SchaneDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0009-0004-1752-8829 Yifan FeiDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0000-0003-1493-8019 Alvaro G HernandezRoy J. Carver Biotechnology Center, The University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0000-0002-6320-1550 Jenny DrnevichRoy J. Carver Biotechnology Center, The University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.
Jefferson ChanBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.
Lawrence W DobruckiBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0000-0002-6807-217X Marni D BoppartBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0000-0003-0369-6974 Julie OstranderMasonic Cancer Center, University of Minnesota, Minneapolis Minnesota, 55455 USA.
Erik R NelsonDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana Illinois, 61801 USA.ORCID 0000-0002-8887-1905 Funding
Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9MImpact of cholesterol and its metabolites on breast cancer progressionR01CA234025 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI NELSON, ERIK RUSSELL · 2019 to 2023
$1.7MNCI NIH HHS R01 CA234025NIBIB NIH HHS T32 EB019944
6 · The paper itselfAbstract
Small extracellular vesicles (sEVs) are emerging as critical mediators of intercellular communication in the tumor microenvironment (TME). Here, we investigate the mechanisms by which sEVs derived from neutrophils treated with the cholesterol metabolite, 27-hydroxycholesterol (27HC), influence breast cancer progression. sEVs released from 27HC treated neutrophils enhance epithelial-mesenchymal transition (EMT) and stem-like properties in breast cancer cells, resulting in loss of adherence, increased migratory capacity and resistance to cytotoxic chemotherapy. Decreased microRNAs (miRs) within the sEVs resulted in activation of the WNT/β-catenin signaling pathway in recipient cells and suggest that this may be a predominant pathway for stem-like phenotype and EMT. Our findings underscore a novel mechanism by which 27HC-modulated neutrophils contribute to breast cancer pathophysiology through EV-mediated intercellular communication, suggesting potential therapeutic targets in cancer treatment.
Indexed as
27-hydroxycholesterolbreast cancerEMTextracellular vesicleneutrophilstemness
Identifiers
PMID39131340
PMCPMC11312600
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
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