Evidence map›Paper›PMID 39131336›Full record

ArticlebioRxiv : the preprint server for biology2024

Calcium phosphate nanoclusters modify periodontium remodeling and minimize orthodontic relapse.

Darnell L Cuylear, Moyu L Fu, Justin C Chau, Bhushan Kharbikar, Galateia J Kazakia, Andrew Jheon, Stefan Habelitz, Sunil D Kapila, Tejal A Desai

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Darnell L CuylearGraduate Program in Oral and Craniofacial Sciences, School of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, United States.ORCID 0000-0002-8120-4501
Moyu L FuSchool of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, United States.
Justin C ChauSchool of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, United States.
Bhushan KharbikarDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco (UCSF), San Francisco, CA, United States.
Galateia J KazakiaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, CA, United States.
Andrew JheonDepartment of Orthodontics and Dentofacial Orthopedics, University of Pittsburgh, Pittsburgh, PA, United States.
Stefan HabelitzDepartment of Preventative and Restorative Dental Sciences, School of Dentistry, University of California, San Francisco (UCSF), CA, United States.
Sunil D KapilaSection of Orthodontics, School of Dentistry, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.
Tejal A DesaiGraduate Program in Oral and Craniofacial Sciences, School of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, United States.

Funding

A proposal for the purchase of a new Cu anode Microsource X-ray Diffractometer wiS10RR027172 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAYMOND, KENNETH N · 2010 to 2010
$500k
Linux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456k
NCRR NIH HHS S10 RR027172NIH HHS S10 OD020054
6 · The paper itself

Abstract

Orthodontic relapse is one of the most prevalent concerns of orthodontic therapy. Relapse results in patients' teeth reverting towards their pretreatment positions, which increases the susceptibility to functional problems, dental disease, and substantially increases the financial burden for retreatment. This phenomenon is thought to be induced by rapid remodeling of the periodontal ligament (PDL) in the early stages and poor bone quality in the later stages. Current therapies, including fixed or removable retainers and fiberotomies, have limitations with patient compliance and invasiveness. Approaches using biocompatible biomaterials, such as calcium phosphate polymer-induced liquid precursors (PILP), is an ideal translational approach for minimizing orthodontic relapse. Here, post-orthodontic relapse is reduced after a single injection of high concentration PILP (HC-PILP) nanoclusters by altering PDL remodeling in the early stage of relapse and improving trabecular bone quality in the later phase. HC-PILP nanoclusters are achieved by using high molecular weight poly aspartic acid (PASP, 14 kDa) and poly acrylic acid (PAA, 450 kDa), which resulted in a stable solution of high calcium and phosphate concentrations without premature precipitation.

Indexed as

Calcium phosphateCollagenFibrillogenesisOrthodontic RelapsePeriodontal ligament

Identifiers

PMID39131336
PMCPMC11312518

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.