In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Xiao ZhangDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-2427-0147 Anurag MajumdarDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Clara KimDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Brian KleiboekerDivision of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3196-1803 Kristann L MageeDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Brian S LearmanDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Steven A ThomasDepartment of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA.
Irfan J LodhiDivision of Endocrinology, Metabolism & Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-6246-9862 Ormond A MacDougaldDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-6907-7960 Erica L SchellerDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-1551-3816 Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MCatecholaminergic Signaling in Normal Cognition, Aging and Models of Alzheimer's DiseaseRF1AG066905 · NIA · UNIVERSITY OF PENNSYLVANIA · PI THOMAS, STEVEN A · 2020 to 2020
$2.5MParathyroid hormone (PTH) modulates lipid metabolism in the skeletal nicheR01AG069795 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RENDINA-RUEDY, ELIZABETH · 2020 to 2025
$2.2MMetabolism and functions of bone marrow adipose tissue in the marrow nicheR01DK137798 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ormond A MacDougald · 2024 to 2026
$1.4MPERIPHERAL NERVE DISTRIBUTION AND FUNCTION WITHIN THE SKELETONU01DK116317 · NIDDK · WASHINGTON UNIVERSITY · PI SCHELLER, ERICA LYNN · 2017 to 2019
$1.1MNeural regulation of skeletal biology and periodontal disease progression in typeR00DE024178 · NIDCR · WASHINGTON UNIVERSITY · PI SCHELLER, ERICA LYNN · 2016 to 2018
$735kMarrow adipocytes modify the neural regulation of boneR56AR081251 · NIAMS · WASHINGTON UNIVERSITY · PI SCHELLER, ERICA LYNN · 2022 to 2022
$341kNIAMS NIH HHS P30 AR074992NIAMS NIH HHS R56 AR081251NIA NIH HHS R01 AG069795NIA NIH HHS RF1 AG066905NIDCR NIH HHS R00 DE024178NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK137798NIDDK NIH HHS U01 DK116317
6 · The paper itselfAbstract
Several adipose depots, including constitutive bone marrow adipose tissue (cBMAT), resist conventional lipolytic cues, making them metabolically non-responsive. However, under starvation, wasting, or cachexia, the body can eventually catabolize these stable adipocytes through unknown mechanisms. To study this, we developed a mouse model of brain-evoked depletion of all fat, including cBMAT, independent of food intake. Genetic, surgical, and chemical approaches demonstrated that depletion of stable fat required adipose triglyceride lipase-dependent lipolysis but was independent of local nerves, the sympathetic nervous system, and catecholamines. Instead, concurrent hypoglycemia and hypoinsulinemia activated a potent catabolic state by suppressing lipid storage and increasing catecholamine-independent lipolysis via downregulation of cell-autonomous lipolytic inhibitors
Identifiers
PMID39131323
PMCPMC11312544
What OpenQuestion holds
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