Evidence map›Paper›PMID 39131266›Full record

ArticlebioRxiv : the preprint server for biology2024

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity.

Jin Young Lee, Nabora Reyes, Sang-Ho Woo, Sakshi Goel, Fia Stratton, Chaoyuan Kuang, Aaron S Mansfield, Lindsay M LaFave, Tien Peng

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jin Young LeeDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine.
Nabora ReyesDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine.
Sang-Ho WooDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine.
Sakshi GoelAlbert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461.
Fia StrattonAlbert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461.
Chaoyuan KuangAlbert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461.
Aaron S MansfieldDepartment of Oncology, Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905.
Lindsay M LaFaveAlbert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461.
Tien PengDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine.

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Mesenchymal modulation of epithelial metaplasia in lung fibrosisR01HL155622 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PENG, TIEN · 2021 to 2024
$2.3M
Deciphering the role of p16INK4A+ fibroblasts in lung fibrosisR01HL160895 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PENG, TIEN · 2022 to 2025
$2.2M
NHLBI NIH HHS R01 HL155622NHLBI NIH HHS R01 HL160895NIDDK NIH HHS P30 DK063720
6 · The paper itself

Abstract

Senescence has been demonstrated to either inhibit or promote tumorigenesis. Resolving this paradox requires spatial mapping and functional characterization of senescent cells in the native tumor niche. Here, we identified senescent

Identifiers

PMID39131266
PMCPMC11312578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.