Evidence map›Paper›PMID 39130968›Full record

ArticleCureus2024

Rituximab-Associated Liver Toxicity Without Known Viral Reactivation.

Taha Huda, Fawaz Hussain, Hariharasudan Mani, Shereen M Gheith, Savitri Skandan

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Taha HudaInternal Medicine, HCA Florida Bayonet Point Hospital, Hudson, USA.
Fawaz HussainInternal Medicine, University of South Florida Morsani College of Medicine, Tampa, USA.
Hariharasudan ManiHematology and Medical Oncology, Lehigh Valley Health Network, Allentown, USA.
Shereen M GheithHematopathology and Clinical Laboratory Medicine, Lehigh Valley Health Network, Allentown, USA.
Savitri SkandanHematology and Medical Oncology, Lehigh Valley Health Network, Allentown, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rituximab is a targeted immunotherapeutic agent that has demonstrated efficacy in treating CD20+ B-cell neoplasms as well as other lymphoproliferative and autoimmune disorders. A major adverse effect of rituximab is hepatocellular injury attributed to hepatitis B viral reactivation, necessitating viral titers before treatment. In this case report, we illustrate the rare presentation of a patient with marginal zone B-cell lymphoma who experienced symptomatic liver injury with a peak 15-fold aminotransferase elevation following his first dose of rituximab, without evidence of viral reactivation.

Indexed as

drug-induced liver injury (dili)hepatotoxicitymarginal zone b cell lymphomarituximabtransaminitis

Identifiers

PMID39130968
PMCPMC11316497

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.