Evidence map›Paper›PMID 39130564›Full record

ArticleACS omega2024

Synergistic Treatment of Breast Cancer by Combining the Antimicrobial Peptide Piscidin with a Modified Glycolipid.

Rebecca T Miceli, Noah G Allen, Bhagyashree Subramaniam, Livia Carmody, Jonathan S Dordick, David T Corr, Myriam Cotten, Richard A Gross

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebecca T MiceliDepartment of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.ORCID https://orcid.org/0000-0002-2297-9219
Noah G AllenDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Bhagyashree SubramaniamDepartment of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Livia CarmodyDepartment of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Jonathan S DordickDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.ORCID https://orcid.org/0000-0001-7802-3702
David T CorrDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.ORCID https://orcid.org/0000-0002-4059-8591
Myriam CottenDepartment of Applied Science, William & Mary, Williamsburg, Virginia 23185, United States.ORCID https://orcid.org/0000-0002-6732-1736
Richard A GrossDepartment of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.ORCID https://orcid.org/0000-0002-5050-3162

Funding

Modular and Project Based Training to Enhance Rigor and Reproducibility in Research for Diverse Biomedical CareersT32GM067545 · NIGMS · RENSSELAER POLYTECHNIC INSTITUTE · PI VASHISHTH, DEEPAK · 2004 to 2020
$3.0M
Endosome-mitochondria interactions in breast cancer cellsR01CA233188 · NCI · ALBANY MEDICAL COLLEGE · PI BARROSO, MARGARIDA · 2020 to 2024
$2.8M
NCI NIH HHS R01 CA233188NIGMS NIH HHS T32 GM067545
6 · The paper itself

Abstract

Piscidin 3 (P3), a peptide produced by fish, and a hexyl ester-modified sophorolipid (SL-HE), have individually shown promise as antimicrobial and anticancer drugs. A recent report by our team revealed that combining P3 with SL-HE in a 1:8 molar ratio resulted in an 8-fold enhancement in peptide activity, while SL-HE improved by 25-fold its antimicrobial activity against the Gram-positive microorganism

Identifiers

PMID39130564
PMCPMC11308023

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.