Evidence map›Paper›PMID 39130513›Full record

ArticleBrain communications2024

Quantitative assessment of enlarged perivascular spaces via deep-learning in community-based older adults reveals independent associations with vascular neuropathologies, vascular risk factors and cognition.

Carles Javierre-Petit, Marinos Kontzialis, Sue E Leurgans, David A Bennett, Julie A Schneider, Konstantinos Arfanakis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Cerebral Amyloid Angiopathy Is Associated With Higher RAnnals of clinical and translational neurology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carles Javierre-PetitDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA.
Marinos KontzialisDepartment of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Sue E LeurgansRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.ORCID https://orcid.org/0000-0003-3689-554X
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Konstantinos ArfanakisDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA.ORCID https://orcid.org/0000-0001-9705-597X

Funding

SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Rush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7M
RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4M
Risk Factors for Cognitive Decline in African-AmericansR01AG022018 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2004 to 2025
$18.2M
Characterizing TDP-43 related hippocampal degeneration and memory loss in agingR01AG067482 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI SCHNEIDER, JULIE A. · 2020 to 2024
$6.8M
MRI markers of brain aging and risk factors for cognitive decline in older African AmericansR01AG056405 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 2018 to 2023
$3.6M
Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementiaU01NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2023 to 2025
$3.5M
Multimodal MRI biomarkers of small vessel disease for older persons with and without dementia.UH3NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2018 to 2020
$3.5M
In-vivo MRI-based prediction of TDP43 pathology in agingR01AG064233 · NIA · ILLINOIS INSTITUTE OF TECHNOLOGY · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2019 to 2023
$3.3M
Comprehensive Longitudinal Probabilistic Atlas of the Brain of Older Adults Without DementiaR01AG052200 · NIA · ILLINOIS INSTITUTE OF TECHNOLOGY · PI ARFANAKIS, KONSTANTINOS · 2016 to 2020
$2.5M
Longitudinal validation of cerebral small vessel disease biomarkers in diverse community-based older adults without dementiaUF1NS100599 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS, SCHNEIDER, JULIE A. · 2021 to 2021
$2.5M
NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG072975NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG052200NIA NIH HHS R01 AG056405NIA NIH HHS R01 AG064233NIA NIH HHS R01 AG067482NINDS NIH HHS U01 NS100599NINDS NIH HHS UF1 NS100599NINDS NIH HHS UH3 NS100599
6 · The paper itself

Abstract

Enlarged perivascular spaces (EPVS) are common in older adults, but their neuropathologic correlates are unclear mainly because most work to date has relied on visual rating scales and/or clinical cohorts. The present study first developed a deep-learning model for automatic segmentation, localization and quantification of EPVS in

Indexed as

cognitiondeep-learningMRIpathologyperivascular spaces

Identifiers

PMID39130513
PMCPMC11316207

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.