Evidence map›Paper›PMID 39130485›Full record

ArticleHeliyon2024

New compatible pair of TCM: Paeoniae Radix Alba effectively alleviate Psoraleae Fructus-induced liver injury by suppressing NLRP3 inflammasome activation.

Yingjie Xu, Xianling Wang, Yan Wang, Longxin Guo, Xiaomei Zhao, Ming Dong, Jincai Wen, Zhixin Wu, Chenyi Li, Wenqing Mu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yingjie XuSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Xianling WangSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Yan WangSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Longxin GuoSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Xiaomei ZhaoSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Ming DongSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Jincai WenSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Zhixin WuSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Chenyi LiSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Wenqing MuSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Yuming GuoDepartment of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, 100039, China.
Zhaofang BaiSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.
Xiaohe XiaoSenior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing, 100039, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Drug-induced liver injury (DILI), a type of acute inflammation, has sparked significant concern owing to its unpredictability and severity. Psoraleae Fructus (PF), an edible Chinese herb widely used in traditional Chinese medicine (TCM), causes liver injury. Therefore, the elucidation of the mechanism underlying PF-induced liver injury and the search for more effective means of detoxification using herbal compatibility has become an urgent issue. This study evaluated the hepatoprotective effects of Paeoniae Radix Alba (PRA), a hepatoprotective Chinese medicine, on PF-induced liver injury and explored the underlying mechanisms. Methods: A rat model of lipopolysaccharide (LPS)-induced immune stress was established to evaluate the hepatotoxicity of PF and the detoxifying effect of PRA. Subsequently, inflammatory pathways were identified using network pharmacology. Finally, the molecular mechanism by which PRA alleviates PF-induced liver injury was validated using an inflammasome activation model in bone marrow-derived macrophages (BMDMs). Results: Conclusions: The present study demonstrates that PRA alleviated PF induced-liver injury by inhibiting NLRP3 inflammasome activation. The results of this study are expected to inform the prevention and control of PF-induced hepatotoxicity in clinical practice.

Indexed as

Detoxification by compatibilityDrug-induced liver injuryNLRP3 inflammasomePaeoniae Radix AlbaPsoraleae Fructus

Identifiers

PMID39130485
PMCPMC11315180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.