Evidence map›Paper›PMID 39130394›Full record

ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2024

Comparison between Effect of Indirect Calorimetry vs Weight-based Equation (25 kcal/kg/day)-guided Nutrition on Quadriceps Muscle Thickness as Assessed by Bedside Ultrasonography in Medical Intensive Care Unit Patients: A Randomized Clinical Trial.

Aravind Chandrasekaran, Divya Pal, Rahul Harne, Sweta J Patel, K N Jagadeesh, Anant V Pachisia, Pooja Tyagi, Keerti Brar, Swagat Pattajoshi, Parimal B Patel and 2 more

Abstract read
In one paragraph

Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Sarcopenia and frailty in critical illness.Current opinion in clinical nutrition and metabolic care · 2025
    Review
  5. Emphasizing Patient-centered Outcomes and Improved Exclusion Criteria in Randomized Controlled Trials for Clinical Nutrition in Critically Ill Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aravind ChandrasekaranDepartment of Critical Care Medicine, K.K. Patel Super Specialty Hospital, Bhuj, Gujarat, India.ORCID https://orcid.org/0009-0005-6075-1580
Divya PalInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0000-0002-1607-3816
Rahul HarneInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0000-0002-0178-2628
Sweta J PatelInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0000-0003-2780-7691
K N JagadeeshInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0000-0002-8396-9954
Anant V PachisiaInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0000-0003-1292-1141
Pooja TyagiInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0009-0005-1247-4443
Keerti BrarInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0009-0005-5346-2457
Swagat PattajoshiInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0009-0003-1644-2735
Parimal B PatelInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0000-0001-8410-0751
Ronak ZatakiyaInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0009-0002-6938-3604
Deepak GovilInstitute of Critical Care and Anaesthesia, Medanta - The Medicity, Gurugram, Haryana, India.ORCID https://orcid.org/0000-0002-4624-1614

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim and background: Sarcopenia is a substantial contributor to intensive care unit (ICU)-acquired weakness and is associated with significant short- and long-term outcomes. It can, however, be mitigated by providing appropriate nutrition. Indirect calorimetry (IC) is believed to be the gold standard in determining caloric targets in the dynamic environment of critical illness. We conducted this study to compare the effect of IC vs weight-based (25 kcal/kg/day) feeding on quadriceps muscle thickness (QMT) by ultrasound in critically ill patients. Materials and methods: A prospective study was conducted on 60 mechanically ventilated patients randomized to two groups [weight-based equation (WBE) group or the IC group] in medical ICU after obtaining institutional ethics committee approval, and fed accordingly. The right QMT measurement using ultrasound and caloric targets were documented on day 1, 3 and 7 and analyzed statistically. The IC readings were obtained from the metabolic cart E-COVX Module Results: The baseline demographics, APACHE-II, NUTRIC score, and SOFA scores on day 1, 3, and 7 were comparable between the two groups. The resting energy expenditure (REE) obtained in the IC group was significantly less than the WBE energy targets and the former were fed with significantly less calories. A significantly less percent reduction of QMT in the IC group compared with the WBE group was observed from day 1 to day 3, day 3 to day 7, and day 1 to day 7. Conclusion: From our study, we conclude that IC-REE-based nutrition is associated with lesser reduction in QMT and lesser calories fed in critically ill mechanically ventilated patients compared from WBE. CTRI registration-CTRI/2023/01/049119. How to cite this article: Chandrasekaran A, Pal D, Harne R, Patel SJ, Jagadeesh KN, Pachisia AV,

Indexed as

Caloric targetCritically illIndirect calorimetryIntensive care unit–acquired weaknessMuscle wastingNutritionQuadriceps muscle thicknessSarcopeniaUltrasound

Identifiers

PMID39130394
PMCPMC11310671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.