Evidence map›Paper›PMID 39130194›Full record

ArticleObesity science & practice2024

The intricate relationship between obesity, type 2 diabetes and female breast cancer: A retrospective study of 335 women.

Ilaria Milani, Chiara Gaita, Gloria Guarisco, Marianna Chinucci, Roberta Parisella, Silvia Piroli, Eleonora Bruno, Annunziata Martellucci, Elena De Falco, Fabio Ricci and 3 more

Abstract read
In one paragraph

Article in Obesity science & practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ilaria MilaniDepartment of Medico-surgical Sciences and Biotechnologies University of Rome La Sapienza Faculty of Pharmacy and Medicine Latina Lazio Italy.ORCID https://orcid.org/0009-0004-0120-4731
Chiara GaitaDepartment of Medico-surgical Sciences and Biotechnologies University of Rome La Sapienza Faculty of Pharmacy and Medicine Latina Lazio Italy.
Gloria GuariscoDepartment of Medico-surgical Sciences and Biotechnologies University of Rome La Sapienza Faculty of Pharmacy and Medicine Latina Lazio Italy.
Marianna ChinucciDepartment of Medico-surgical Sciences and Biotechnologies University of Rome La Sapienza Faculty of Pharmacy and Medicine Latina Lazio Italy.
Roberta ParisellaBreast Unit Hospital Santa Maria Goretti Latina Lazio Italy.
Silvia PiroliBreast Unit Hospital Santa Maria Goretti Latina Lazio Italy.
Eleonora BrunoBreast Unit Hospital Santa Maria Goretti Latina Lazio Italy.
Annunziata MartellucciBreast Unit Hospital Santa Maria Goretti Latina Lazio Italy.
Elena De FalcoDepartment of Medico-surgical Sciences and Biotechnologies University of Rome La Sapienza Faculty of Pharmacy and Medicine Latina Lazio Italy.
Fabio RicciBreast Unit Hospital Santa Maria Goretti Latina Lazio Italy.
Antonella CalogeroDepartment of Medico-surgical Sciences and Biotechnologies University of Rome La Sapienza Faculty of Pharmacy and Medicine Latina Lazio Italy.
Frida LeonettiDepartment of Medico-surgical Sciences and Biotechnologies University of Rome La Sapienza Faculty of Pharmacy and Medicine Latina Lazio Italy.ORCID https://orcid.org/0000-0002-5606-8448
Danila CapocciaDepartment of Medico-surgical Sciences and Biotechnologies University of Rome La Sapienza Faculty of Pharmacy and Medicine Latina Lazio Italy.ORCID https://orcid.org/0000-0003-1674-6686

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Type 2 diabetes (T2D) is a risk factor for female breast cancer (FBC). Obesity has also been associated with FBC, also depending on menopausal status. This study aimed to evaluate the impact of obesity and T2D on the development, aggressiveness, and invasiveness of FBC. Methods: Demographic, clinical, and histopathological data from 335 women with FBC were collected, and analyzed according to weight category (102 normal weight, 117 overweight, and 116 living with obesity) and the presence/absence of T2D. Results: Age at oncologic diagnosis was not statistically significantly different for body weight; women with overweight or obesity were more likely to have an oncologic diagnosis after menopause than normal weight ( Conclusions: These results confirm excess body weight and T2D as unfavorable prognostic factors in terms of the presence of the TNBC subtype, tumor metastasis, recurrence, and aggressiveness (G3 and Ki-67 > 20%). This study highlights the importance of prevention in all women, with early screening, and adequate nutritional programs.

Indexed as

breast cancerhistologymenopauseobesitytype 2 diabetes

Identifiers

PMID39130194
PMCPMC11310762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.